The assembly, regulation and function of the mitochondrial respiratory chain
I Vercellino, LA Sazanov - Nature reviews Molecular cell biology, 2022 - nature.com
The mitochondrial oxidative phosphorylation system is central to cellular metabolism. It
comprises five enzymatic complexes and two mobile electron carriers that work in a …
comprises five enzymatic complexes and two mobile electron carriers that work in a …
Modular biogenesis of mitochondrial respiratory complexes
Mitochondrial function relies on the activity of oxidative phosphorylation to synthesise ATP
and generate an electrochemical gradient across the inner mitochondrial membrane. These …
and generate an electrochemical gradient across the inner mitochondrial membrane. These …
Respiratory supercomplexes: structure, function and assembly
The mitochondrial respiratory chain consists of 5 enzyme complexes that are responsible for
ATP generation. The paradigm of the electron transport chain as discrete enzymes diffused …
ATP generation. The paradigm of the electron transport chain as discrete enzymes diffused …
Supramolecular organisation of the mitochondrial respiratory chain: a new challenge for the mechanism and control of oxidative phosphorylation
G Lenaz, ML Genova - … : nuclear-encoded genes, enzyme regulation, and …, 2012 - Springer
Recent experimental evidence has replaced the random diffusion model of electron transfer
with a model of supramolecular organisation based on specific interactions between …
with a model of supramolecular organisation based on specific interactions between …
Questioning the functional relevance of mitochondrial supercomplexes by time-resolved analysis of the respiratory chain
M Trouillard, B Meunier… - Proceedings of the …, 2011 - National Acad Sciences
Mitochondria are the powerhouses of eukaryotic cells as they feed metabolism with its major
substrate. Oxidative-phosphorylation relies on the generation, by an electron/proton transfer …
substrate. Oxidative-phosphorylation relies on the generation, by an electron/proton transfer …
The functional significance of mitochondrial respiratory chain supercomplexes
The mitochondrial respiratory chain (MRC) is a key energy transducer in eukaryotic cells.
Four respiratory chain complexes cooperate in the transfer of electrons derived from various …
Four respiratory chain complexes cooperate in the transfer of electrons derived from various …
Structural and functional organization of the mitochondrial respiratory chain: a dynamic super-assembly
G Lenaz, ML Genova - The International Journal of Biochemistry & Cell …, 2009 - Elsevier
The structural organization of the mitochondrial oxidative phosphorylation (OXPHOS)
system has received large attention in the past and most investigations led to the conclusion …
system has received large attention in the past and most investigations led to the conclusion …
Respiratory chain supercomplexes: structures, function and biogenesis
T Lobo-Jarne, C Ugalde - Seminars in cell & developmental biology, 2018 - Elsevier
Over the past sixty years, researchers have made outmost efforts to clarify the structural
organization and functional regulation of the complexes that configure the mitochondrial …
organization and functional regulation of the complexes that configure the mitochondrial …
Analysis of mitochondrial respiratory chain supercomplexes using blue native polyacrylamide gel electrophoresis (BN‐PAGE)
Mitochondria are cellular organelles that harvest energy in the form of ATP through a
process termed oxidative phosphorylation (OXPHOS), which occurs via the protein …
process termed oxidative phosphorylation (OXPHOS), which occurs via the protein …
Supramolecular structure of the mitochondrial oxidative phosphorylation system
EJ Boekema, HP Braun - Journal of Biological Chemistry, 2007 - ASBMB
The protein complexes of the mitochondrial oxidative phosphorylation system were recently
reported to form supramolecular assemblies termed respiratory supercomplexes or …
reported to form supramolecular assemblies termed respiratory supercomplexes or …