Multiple antibiotic resistance of clinically important bacteria are of major concern worldwide.
Alterations of drug targets or enzymatic inactivation of antimicrobial agents are the well …

The process of active efflux, the last described resistance mechanism in bacteria, is one of
the important factors of acquired antibiotic resistance. Efflux systems which consist of …

Pseudomonas aeruginosa is an opportunistic human pathogen characterized by an innate
resistance to multiple antimicrobial agents. A major contribution to this intrinsic multidrug …

Multidrug efflux transporters are normal constituents of bacterial cells. These transporters
are major contributors to intrinsic resistance of bacteria to many anti-microbial agents. In …

Multidrug resistance is a major problem in the treatment of infectious diseases caused by
bacteria and fungi. One of the basic mechanisms of resistance is active efflux of distinct …

Active efflux is a common resistance mechanism in a wide range of bacterial pathogens. It is
responsible for the transport of such toxic compounds as drugs, toxins, and detergents …

The development of multidrug resistance in Gram-negative bacteria is a major problem
faced antimicrobial therapy and management of infectious diseases. Too many resistance …

Multidrug efflux mechanisms in bacteria contribute significantly to intrinsic and acquired
resistance to antimicrobial agents. Genome analysis have confirmed the broad distribution …

Antibiotic resistance mechanisms reported in Gram-negative bacteria are causing a
worldwide health problem. The continuous dissemination of 'multidrug-resistant'(MDR) …

Active efflux of antibiotics is one of the major mechanisms of drug resistance in bacteria. The
efflux process is mediated by membrane transporters with a large variety of unrelated …