Increased microparticle tissue factor activity in cancer patients with venous thromboembolism

DA Manly, J Wang, SL Glover, R Kasthuri… - Thrombosis research, 2010 - Elsevier
Cancer patients exhibit a high rate of thromboembolism (VTE). In this study, we analyzed
levels of microparticle (MP) tissue factor (TF) activity in cancer patients with or without VTE …

[HTML][HTML] Microparticle‐associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients

J THALER, C Ay, N Mackman, RM Bertina… - Journal of Thrombosis …, 2012 - Elsevier
Background: Tissue factor (TF) expression by tumors contributes to tumor growth. Release of
TF‐positive microparticles (MPs) may contribute to venous thromboembolism (VTE) …

Microparticle-associated tissue factor activity in cancer patients with and without thrombosis

MET Tesselaar, F Romijn, IK Van Der Linden… - Journal of Thrombosis …, 2009 - jthjournal.org
In a previous study [1], we found that the tissue factor (TF) activity of microparticles (MP)
isolated from platelet-poor plasma (MP-TF activity) was markedly increased in patients with …

[HTML][HTML] Microparticle‐associated tissue factor activity: a link between cancer and thrombosis?

MET Tesselaar, F Romijn, IK Van Der Linden… - Journal of thrombosis …, 2007 - Elsevier
Background: Cancer, in particular mucinous adenocarcinoma, is associated with venous
thromboembolism (VTE). Tissue factor (TF), initiator of coagulation, plays a central role in the …

Tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients

C Hernández, J Orbe, C Roncal… - Thrombosis and …, 2013 - thieme-connect.com
A prothrombotic state is one of the hallmarks of malignancy and a major contributor to
morbidity and mortality in cancer patients. Tissue factor (TF) is often overexpressed in …

Tumor-derived tissue factor–positive microparticles and venous thrombosis in cancer patients

JE Geddings, N Mackman - Blood, The Journal of the American …, 2013 - ashpublications.org
Patients with cancer have an increased risk for venous thrombosis. Interestingly, different
cancer types have different rates of thrombosis, with pancreatic cancer having one of the …

Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients

RE Tilley, T Holscher, R Belani, J Nieva… - Thrombosis research, 2008 - Elsevier
BACKGROUND: Cancer patients have an increased risk of thrombosis. Tissue factor (TF)
antigen and TF activity associated with microparticles in plasma are elevated in patients with …

Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer

AA Khorana, CW Francis, KE Menzies… - Journal of Thrombosis …, 2008 - jthjournal.org
Pancreatic cancer is the fourth leading cause of cancer death in the US [1]. It is frequently
complicated by venous thromboembolism (VTE), with published incidence rates varying …

Microparticle-associated tissue factor activity in patients with metastatic pancreatic cancer and its effect on fibrin clot formation

J Thaler, S Koder, G Kornek, I Pabinger, C Ay - Translational Research, 2014 - Elsevier
Highly elevated microparticle (MP)-associated tissue factor (TF) activity was found in
patients with pancreatic cancer, one of the most prothrombotic malignancies. It remains to be …

Tumour and microparticle tissue factor expression and cancer thrombosis

K Date, J Hall, J Greenman, A Maraveyas… - Thrombosis research, 2013 - Elsevier
Cancer is frequently complicated by venous thromboembolic events (VTE), which pose a
significant health burden due to the associated high morbidity and mortality rates, yet the …