Effects of quinidine on membrane currents forming the plateau of action potentials were
studied using an isolated single ventricular cell from guinea-pig hearts. Quinidine (5 mg/l) …

We examined the effects of quinidine (5-20 microM) on transmembrane action potentials
and ionic currents of isolated canine ventricular myocytes. Collagenase treatment of canine …

1 The effects of quinidine on calcium‐independent outward K+ currents in rat ventricular
myocytes were studied using whole‐cell patch clamp techniques. 2 Quinidine sulphate (6 …

Prolongation of cardiac action potentials may mediate some of the arrhythmia-suppressing
and arrhythmia-aggravating actions of antiarrhythmic agents. In this study, suppression of …

A major action of the antiarrhythmic agent quinidine is prolongation of cardiac repolarization.
In these experiments, the time-dependent effects of quinidine on the delayed rectifier …

Quinidine is frequently used as a class I antiarrhythmic agent in the management of cardiac
rhythm disturbances. It depresses the rapid initial depolarization of the action potential by …

In guinea pig cardiac myocytes quinidine (20 microM) caused less than 10% tonic block
reduction of the sodium current at-120 mV, but a fast pulse train reduced it more than 90 …

Age-related cardiac actions of quinidine have been shown in prolongation of action potential
duration, but not in the tonic and use-dependent block of the maximal velocity of action …

The actions of ambasilide (LU-47110) on the action potential and membrane currents of
isolated guinea pig ventricular myocytes were studied using voltage clamp techniques …

The effects of N-acetylprocainamide (NAPA) and sotalol on membrane current systems of
guinea-pig ventricular myocytes were examined and compared with those of quinidine using …