The transcription factor CREB is best known for its involvement in learning and memory.
However, emerging evidence suggests that CREB activity has very different roles …

The transcription factor CREB has been implicated in signalling pathways relevant for
pathogenesis and therapy of depression. CREB is upregulated and activated in the …

Major depressive disorder is a severe clinical problem across the globe, with a lifetime risk
of 10%–30% for women and 7%–15% for men. The World Health Organization ranks major …

CREB and its close relatives are now widely accepted as prototypical stimulus-inducible
transcription factors. In many cell types, these factors function as effector molecules that …

In neurons, appropriate long-term adaptive responses to changes in the environment
require the conversion of extracellular stimuli into discrete intracellular signals. Many of …

The transcription factor cAMP response element binding protein (CREB) has been
implicated in the long‐term neuronal plasticity associated with addiction. While CREB is …

In neurons, the convergence of multiple intracellular signaling cascades leading to cAMP-
responsive element-binding protein (CREB) activation suggests that this transcription factor …

J. Neurochem.(2011) 116, 1–9. Abstract Since its initial characterization over 20 years ago,
there has been intense and unwavering interest in understanding the role of the …

The activation of cAMP-response element binding protein (CREB)-dependent gene
expression seems a crucial step in the molecular cascade that mediates the formation of …

The transcription factor cAMP-responsive element binding protein (CREB) has been shown
to regulate different physiological responses including drug addiction and emotional …