Berberine ameliorates rats model of combined Alzheimer's disease and type 2 diabetes mellitus via the suppression of endoplasmic reticulum stress
W Xuan, H Wang, P Zhou, T Ye, H Gao, S Ye, J Wang… - 3 Biotech, 2020 - Springer
This study is aimed to investigate the protective effect against type 2 diabetes mellitus
(T2DM) and Alzheimer's disease (AD) of Berberine (BBR), and the underlying mechanism of …
(T2DM) and Alzheimer's disease (AD) of Berberine (BBR), and the underlying mechanism of …
Berberine ameliorates diabetes-associated cognitive decline through modulation of aberrant inflammation response and insulin signaling pathway in DM rats
Q Chen, R Mo, N Wu, X Zou, C Shi, J Gong… - Frontiers in …, 2017 - frontiersin.org
Background: Memory-impairment was one of the common characteristics in patients with
diabetes mellitus. The release of chronic inflammation mediators and insulin resistance in …
diabetes mellitus. The release of chronic inflammation mediators and insulin resistance in …
Berberine Improves Diabetic Encephalopathy Through the SIRT1/ER Stress Pathway in db/db Mice
HY Li, XC Wang, YM Xu, NC Luo, S Luo… - Rejuvenation …, 2018 - liebertpub.com
The association between diabetes and dementia has been well demonstrated by
epidemiologic studies. Berberine (BBR) has been reported to ameliorate diabetes and …
epidemiologic studies. Berberine (BBR) has been reported to ameliorate diabetes and …
Berberine ameliorates spatial learning memory impairment and modulates cholinergic anti-inflammatory pathway in diabetic rats
K Wang, Q Chen, N Wu, Y Li, R Zhang… - Frontiers in …, 2019 - frontiersin.org
Background: Cognitive impairment caused by diabetes has been recognized. Berberine is
well known for its resistance to peripheral lesions, but it is rarely used for the treatment of …
well known for its resistance to peripheral lesions, but it is rarely used for the treatment of …
Effects of berberine on diabetes and cognitive impairment in an animal model: the mechanisms of action
JH Zhang, JF Zhang, J Song, Y Bai, L Deng… - The American journal …, 2021 - World Scientific
Diabetes is a group of metabolic disorders with an increased risk of developing cognitive
impairment and dementia. The hippocampus in the forebrain contains an abundance of …
impairment and dementia. The hippocampus in the forebrain contains an abundance of …
Berberine chloride can ameliorate the spatial memory impairment and increase the expression of interleukin-1beta and inducible nitric oxide synthase in the rat model …
F Zhu, C Qian - BMC neuroscience, 2006 - Springer
Background Berberine is the major alkaloidal component of Rhizoma coptidis, and has
multiple pharmacological effects including inhibiting acetylcholinesterase, reducing …
multiple pharmacological effects including inhibiting acetylcholinesterase, reducing …
Network pharmacology reveals that Berberine may function against Alzheimer's disease via the AKT signaling pathway
W Wei, J Yao, T Zhang, J Wen, Z Zhang… - Frontiers in …, 2023 - frontiersin.org
Objective To investigate the mechanism underlying the effects of berberine (BBR) in the
treatment of Alzheimer's disease (AD). Methods 3× Tg AD mice were treated with BBR for 3 …
treatment of Alzheimer's disease (AD). Methods 3× Tg AD mice were treated with BBR for 3 …
Berberine alleviates tau hyperphosphorylation and axonopathy-associated with diabetic encephalopathy via restoring PI3K/Akt/GSK3β pathway
S Wang, B He, W Hang, NH Wu, L Xia… - Journal of …, 2018 - content.iospress.com
Background: Axonopathy is closely linked to the development of diabetic encephalopathy
induced by type II diabetes (T2D). Berberine has been shown to cross the blood-brain …
induced by type II diabetes (T2D). Berberine has been shown to cross the blood-brain …
[HTML][HTML] Berberine elevates mitochondrial membrane potential and decreases reactive oxygen species by inhibiting the Rho/ROCK pathway in rats with diabetic …
L Tian, H Ri, J Qi, P Fu - Molecular pain, 2021 - ncbi.nlm.nih.gov
Objectives Diabetic encephalopathy (DE) is a serious complication of diabetes mainly
occurring in the elderly patients. Berberine (BBR) is an isoquinoline alkaloids extracted from …
occurring in the elderly patients. Berberine (BBR) is an isoquinoline alkaloids extracted from …
Berberine ameliorates cognitive disorder via gsk3β/PGC-1α signaling in APP/PS1 mice
M Yang, J Wang - Journal of Nutritional Science and Vitaminology, 2022 - jstage.jst.go.jp
Previous studies have revealed that Berberine (BBR) had therapeutic effects on Alzheimer's
disease (AD). However, the underlying mechanism of BBR in the treatment of AD is unclear …
disease (AD). However, the underlying mechanism of BBR in the treatment of AD is unclear …