The significance of urinary total hydroxyproline in clinical medicine has been established as
an indicator of the rate of collagen metabolism. It has been employed in assessing the …

Excretion of hydroxyproline in urine was estimated in 48 children with different disorders and
in 92 children with no apparent change in collagen metabolism. Values were high in …

The daily urinary excretion of endogenous hydroxyproline is believed to be a reliable index
of collagen turnover, particularly the collagen matrix of bone (Ziff et al., 1956; Prockop and …

Beginning with the report of Ziff, Kibrick, Dresner, and Gribetz (2), evidence accumulated in
recent years has indicated that urinary hydroxyproline excretion reflects collagen …

Isotopic studies have indicated that the hydroxyproline excreted in urine is derived primarily
from the degradation of collagen (1, 2), and that the excretion of hydroxyproline can be used …

Hydroxyproline excretion has become a useful clinical index of collagen metabolism in man.
Its significance is based on the fact that this amino acid, which is found in no other protein of …

Twenty-four hour urinary total hydroxyproline was measured in 70 normal males and 10
normal females between the ages of 5 through 49. Normal values for excretion of …

Urine total, free and peptide bound hydroxyproline excretion have been measured at regular
intervals after birth in 5 infants with gestations from 32 to 34 weeks and in 2 infants with …

Since practically all of the hydroxyproline in the body is found in the collagen, it is very
probable that the rate of excretion of this compound will furnish an index of turnover of bone …

3-trans-hydroxyproline is a hydroxyproline isomer present in collagens. It is more abundant
in basement membrane collagen (collagen type IV) where it can be found in a relation of 12 …