Arp2/3 complex is bound and activated by two WASP proteins
SB Padrick, LK Doolittle… - Proceedings of the …, 2011 - National Acad Sciences
Actin related protein 2/actin related protein 3 (Arp2/3) complex nucleates new actin filaments
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …
in eukaryotic cells in response to signals from proteins in the Wiskott–Aldrich syndrome …
Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP
GOC Cory, R Cramer, L Blanchoin, AJ Ridley - Molecular cell, 2003 - cell.com
Wiskott-Aldrich syndrome protein (WASP) and neural (N)-WASP regulate dynamic actin
structures through the ability of their VCA domains to bind to and stimulate the actin …
structures through the ability of their VCA domains to bind to and stimulate the actin …
Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex
TH Millard, SJ Sharp, LM Machesky - Biochemical Journal, 2004 - portlandpress.com
The assembly of a branched network of actin filaments provides the mechanical propulsion
that drives a range of dynamic cellular processes, including cell motility. The Arp2/3 complex …
that drives a range of dynamic cellular processes, including cell motility. The Arp2/3 complex …
Activation of Arp2/3 complex by Wiskott-Aldrich Syndrome protein is linked to enhanced binding of ATP to Arp2
C Le Clainche, D Didry, MF Carlier… - Journal of Biological …, 2001 - ASBMB
In response to signaling, the Arp2/3 complex (actin-related proteins 2 and 3 complex) is
activated by binding the C-terminal (WA) domain of proteins of the Wiskott-Aldrich Syndrome …
activated by binding the C-terminal (WA) domain of proteins of the Wiskott-Aldrich Syndrome …
Role and structural mechanism of WASP-triggered conformational changes in branched actin filament nucleation by Arp2/3 complex
M Rodnick-Smith, Q Luan, SL Liu… - Proceedings of the …, 2016 - National Acad Sciences
The Arp2/3 (Actin-related proteins 2/3) complex is activated by WASP (Wiskott–Aldrich
syndrome protein) family proteins to nucleate branched actin filaments that are important for …
syndrome protein) family proteins to nucleate branched actin filaments that are important for …
The Wiskott–Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex
Actin polymerization at the cell cortex is thought to provide the driving force for aspects of
cell-shape change and locomotion. To coordinate cellular movements, the initiation of actin …
cell-shape change and locomotion. To coordinate cellular movements, the initiation of actin …
Critical conformational changes in the Arp2/3 complex are induced by nucleotide and nucleation promoting factor
Actin nucleation and branching by the Arp2/3 complex is tightly regulated by activating
factors. However, the mechanism of Arp2/3 complex activation remains unclear. We used …
factors. However, the mechanism of Arp2/3 complex activation remains unclear. We used …
Activation of Arp2/3 complex: addition of the first subunit of the new filament by a WASP protein triggers rapid ATP hydrolysis on Arp2
MJ Dayel, RD Mullins - PLoS biology, 2004 - journals.plos.org
In response to activation by WASP-family proteins, the Arp2/3 complex nucleates new actin
filaments from the sides of preexisting filaments. The Arp2/3-activating (VCA) region of …
filaments from the sides of preexisting filaments. The Arp2/3-activating (VCA) region of …
The verprolin-like central (vc) region of Wiskott-Aldrich syndrome protein induces Arp2/3 complex-dependent actin nucleation
K Hufner, HN Higgs, TD Pollard, C Jacobi… - Journal of Biological …, 2001 - ASBMB
Wiskott-Aldrich Syndrome protein (WASp) and related proteins stimulate actin filament
nucleation by Arp2/3 complex. The isolated C-terminal VCA domain of WASp …
nucleation by Arp2/3 complex. The isolated C-terminal VCA domain of WASp …
Actin-binding proteins
SJ Winder, KR Ayscough - Journal of cell science, 2005 - journals.biologists.com
652 is energetically unfavourable until there is a nucleus of three associating monomers and
in vitro this stage of filament formation is denoted the lag phase. In vivo, ABPs are crucial to …
in vitro this stage of filament formation is denoted the lag phase. In vivo, ABPs are crucial to …