Sickle cell disorders, such as Hb SS and Hb SC, are associated with a hypercoagulable
state that may contribute to the vaso‐occlusive episodes observed in the disorders. To what …

Recent epidemiologic data suggest that sickle cell trait (Hb AS; AS) is a risk factor for venous
thromboembolism. We conducted an exploratory study of healthy subjects with AS under …

Seventeen parameters of coagulation and fibrinolysis were measured in 33 patients with
sickle cell disease; 30 were tested in steady state (SS) and 19 in crisis (Cr). There were 16 …

In the present study we examined if, among other mechanisms, the abnormal exposure of
phosphatidylserine at the surface of sickle red blood cells (RBCs) contributes to the …

Complex pertubations of hemostasis occur in sickle cell disease (SCD). Although the
procoagulant property of sickle erythrocytes in vitro is tied to exposure of phosphatidylserine …

People with sickle cell disease have a chronically activated coagulation system and display
hemostatic perturbations, but it is unknown whether they experience an increased risk of …

Abstract Changes in several components of the clotting system are well documented in
sickle cell disease (SCD) patients. However, whether the global hemostatic potential of …

Chronic activation of coagulation is one of the features of sickle cell disease (SCD).
Increased tissue factor expression, phosphatidylserine exposure, thrombin generation and …

Microvascular and macrovascular thrombosis is thought to contribute significantly to the
pathophysiology of complications in sickle cell disease (SCD). 1, 2 The mechanism of …

Thirty-three subjects with sickle cell disease (SCD), 11 during episodes of pain and 22
during periods without pain, were evaluated for in vivo thrombogenic activities as compared …