Purpose: Cultured tumor fragments from melanoma metastases have been used for years as
a source of tumor-infiltrating lymphocytes (TIL) for adoptive cell therapy (ACT). The …

Tumor-specific tumor-infiltrating lymphocytes (TILs) can be in vitro expanded and have the
ability to induce complete and durable tumor regression in some patients with melanoma …

Adoptive T-cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) can induce tumor
regression in up to 50% or more of patients with unresectable metastatic melanoma …

Abstract Treatment of patients with adoptive T-cell therapy requires expansion of unique
tumor-infiltrating lymphocyte (TIL) cultures from single-cell suspensions processed from …

Adoptive cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL) for metastatic
melanoma has shown objective response rates as high as 72%. The successful application …

Purpose: Adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL) is a
therapy for metastatic melanoma with response rates of up to 50%. However, the generation …

Adoptive cell therapy using tumor-infiltrating lymphocytes (TIL) can mediate objective and
durable tumor regressions in patients with metastatic melanoma. CD8+ tumor-reactive TIL …

Adoptive cell therapy (ACT) with tumor-reactive lymphocytes in patients with refractory
melanoma can result in tumor regression and prolonged survival. Generating tumor-reactive …

BACKGROUND: Clinical application of adoptive T cell therapy has been hindered by an
inability to generate adequate numbers of nontolerized, functionally active, tumor-specific T …

Adoptive T-cell therapy (ACT) using expanded tumor-infiltrating lymphocytes (TIL) with high-
dose interleukin-2 is a promising form of immunotherapy for stage IV melanoma having …