Renal amyloidosis is a rare condition caused by the progressive accumulation of misfolded
proteins within glomeruli, vessels, and interstitium, causing functional decline and requiring …

Early diagnosis and classification of amyloid deposition and differentiation from other
glomerular fibrillar deposits relies on routine Congo red (CR) histochemistry. Congo red …

Rationale & Objective Congo Red positivity with birefringence under polarized light has
traditionally permitted classification of organized glomerular deposits as from amyloid or …

Our understanding of renal diseases with structured deposits has improved in the last two
decades with the development of new diagnostic techniques that also changed the role of …

Amyloidosis is a heterogeneous group of protein misfolding diseases characterized by
deposition of amyloid proteins. The kidney is frequently affected, especially by …

The tissue diagnosis of amyloidosis and confirmation of fibril protein type, which are crucial
for clinical management, have traditionally relied on Congo red (CR) staining followed by …

Diagnosis of amyloid beyond Congo red : Current Opinion in Nephrology and Hypertension
Diagnosis of amyloid beyond Congo red : Current Opinion in Nephrology and Hypertension …

Aims Identification and characterisation of monoclonal gammopathies of renal significance
(MGRS) is critical for therapeutic purposes. Amyloidosis represents one of the most common …

Background Minimal change disease (MCD) accounts for 10–15% of all adult nephrotic
syndrome cases and requires normal renal histology by light microscopy and negative …

Systemic amyloidosis is a devastating group of disorders for which there is no current cure.
The treatment goal is to reduce the burden of amyloidogenic protein precursors. The …