The food-borne bacterial pathogen Salmonella Typhimurium uses a type III protein secretion
system to deliver multiple proteins into host cells. These secreted effectors modulate the …

Many intracellular pathogens have evolved highly specialized mechanisms to isolate
themselves from the host cell's innate immune response while still obtaining the necessary …

Salmonella utilizes translocated virulence proteins (termed effectors) to promote host cell
invasion. The effector SopD contributes to invasion by promoting scission of the plasma …

Microbial infections usually lead to host innate immune responses and inflammation. These
responses most often limit pathogen replication although they can also result in host-tissue …

Salmonella Typhimurium stimulates inflammatory responses in the intestinal epithelium,
which are essential for its ability to replicate within the intestinal tract. Stimulation of these …

Cell-autonomous defense mechanisms are potent strategies that protect individual cells
against intracellular pathogens. The Rab-family GTPase Rab32 was previously shown to …

Recognition of conserved bacterial products by innate immune receptors leads to
inflammatory responses that control pathogen spread but that can also result in pathology …

Intracellular bacterial pathogens of a diverse nature share the ability to evade host immunity
by impairing trafficking of endocytic cargo to lysosomes for degradation, a process that is …

Acute gastroenteritis caused by Salmonella enterica serovar typhimurium is a significant
public health problem. This pathogen has very sophisticated molecular machinery encoded …

Enteritis induced by non‐typhoid pathogenic Salmonella is characterized by fluid secretion
and inflammatory responses in the infected ileum. The inflammatory response provoked by …