Netrin-1 was recently proposed to control tumorigenesis by inhibiting apoptosis induced by
the dependence receptors DCC (Deleted in colorectal cancer) and UNC5H. Although the …

In this review, we will develop the different data supporting the view that a selective
advantage for a tumor is to inactivate this dependence receptor's proapoptotic signal and …

Background Netrin-1 may promote colorectal and breast tumorigenesis, by inhibiting
apoptosis induced by its dependence receptors, deleted in colorectal cancer (DCC) and …

A novel way of seeing cellular receptors has recently emerged. While a receptor used to be
considered as inactive until bound by its ligand, it has been proposed that some receptors …

Netrin-1, a secreted protein recently characterized as a relevant cancer therapeutic target, is
the antiapoptotic ligand of the dependence receptors deleted in colorectal carcinoma and …

Netrin-1 and its receptors DCC (deleted in colorectal cancer) and the UNC5 orthologues
(human UNC5A–D and rodent UNC5H1–4) define a new mechanism for both the positive …

The secreted factor netrin‐1 is upregulated in a fraction of human cancers as a mechanism
to block apoptosis induced by netrin‐1 dependence receptors DCC and UNC5H. Targeted …

Netrin-1 has been shown to be up-regulated in a fraction of human cancers as a mechanism
to allow these tumors to escape the pro-apoptotic activity of some of its main dependence …

Background: Netrin-1 belongs to a family of secreted proteins that act as migration and
adhesion cues in the developing CNS and in a number of non-neural tissues. Netrin-1 is the …

Netrin-1, discovered as a neuronal navigation cue, has been recently proposed to play a
crucial role during colorectal tumorigenesis by regulating apoptosis. This survival activity is …