The enzymes of the poly-ADP-ribose polymerase (PARP) superfamily control many relevant
cellular processes, but a precise understanding of their activities in different physiological or …

PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular
pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly …

Innate immune cells are critical in protective immunity against viral infections, involved in
sensing foreign viral nucleic acids. Here we report that the poly (ADP-ribose) polymerase 9 …

Transcriptome analyses have recently identified PARP12, a member of a large family of ADP-
ribosyl transferases, as an interferon-induced gene (ISG), whose function remains …

Over 300 posttranslational modifications (PTMs) are known to modify the functions of
proteins by affecting processes ranging from activation, degradation, localization, secretion …

ADP ribosylation has been recently recognised as an important posttranslational
modification regulating numerous cellular processes. This enzymatic activity is shared by …

The mono-ADP-ribosyltransferase PARP7 has emerged as a key negative regulator of
cytosolic NA-sensors of the innate immune system. We apply a rational design strategy for …

SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for
coronavirus pathogenesis and is thus an attractive target for drug development. This …

STAT1α is a key transcription factor driving pro-inflammatory responses in macrophages.
We found that the interferon gamma (IFNγ)-regulated transcriptional program in …

ADP-ribosylation is a post-translational modification that, until recently, has remained
elusive to study at the cellular level. Previously dependent on radioactive tracers to identify …