Regulatory T (Treg) cells are essential in preventing the host from developing certain
autoimmune diseases and limiting excessive immune responses against pathogens. The …

Foxp3 is responsible for the major immunological features of Treg cells, including
hypoproliferation in vitro, immune suppression of conventional T cells and resistance to Th2 …

Regulatory T cells are capable of suppressing deleterious immune responses against self-or
non-self-antigens. Their essential role in tolerance and immune regulation has been …

While mutations in human FOXP3 predispose individuals to autoimmune conditions, it is
unclear how the mutant protein fails to function as a transcriptional regulator. There is also …

Regulatory T cells that express the Foxp3 transcription factor play important roles in
preventing autoimmune diseases. Although several studies have demonstrated that the lack …

Regulatory T cells (Tregs) are a specialized subset of CD4+ T cells essential for the
maintenance of immune homeostasis and prevention of autoimmunity. Treg lineage and …

The forkhead/winged-helix transcription factor FOXP3 confers suppressive ability to CD4+
FOXP3+ regulatory T (Treg) cells. Human Treg cells express several different isoforms of …

FOXP3 is the master transcription factor in both murine and human FOXP3+ regulatory T
cells (Tregs), a T-cell subset with a central role in controlling immune responses. Loss of the …

Foxp3, an X chromosome–encoded forkhead transcription factor family member, is
indispensable for the differentiation of regulatory T cells. These cells have a vital role in …

Abstract The Transcription factor FoxP3belongs to the forkhead/winged-helix
familyoftranscriptional regulators and shares general structural features with other FoxP …