HIV-1 protease is an obligatory enzyme in the replication process of the HIV virus. The
abundance of structural information on HIV-1PR has made the enzyme an attractive target …

In order to well understand the chemical-biological interactions governing their activities
toward HIV protease activity, QSAR models of 34 cyclic-urea derivatives with inhibitory HIV …

HIV-1 protease is a key enzyme for viral maturation because it cleaves precursor
polypeptides into mature structural and functional proteins. The introduction of protease …

Background Tremendous research from last twenty years has been pursued to cure human
life against HIV virus. A large number of HIV protease inhibitors are in clinical trials but still it …

Receptor-dependent (RD) 4D-QSAR models were constructed for a set of 39 4-hydroxy-5, 6-
dihydropyrone analogue HIV-1 protease inhibitors. The receptor model used in this QSAR …

Introduction Despite the availability of FDA approved inhibitors of HIV protease, numerous
efforts are still ongoing to achieve 'near-perfect'drugs devoid of characteristic adverse side …

Human immunodeficiency virus type 1 protease (HIV-1 PR) is an essential enzyme for the
replication cycle of HIV-1. HIV-1 PR inhibitors have been extensively investigated as anti …

Three-dimensional quantitative structure− activity relationship (3D-QSAR) models have
been developed using comparative molecular field analysis (CoMFA) on a large data set …

Abstact 3D-QSAR studies using the Comparative Molecular Field Analysis (CoMFA)
methodology were conducted to predict the inhibition constants, K i, and the inhibitor …

The HIV protease enzyme (maturation enzyme) is one of the most promising therapeutic
targets for the treatment of AIDS. Due to the mutation in the virus, there is always room for …