Each level of DNA folding in cells corresponds to a distinct chromatin structure. The basic
chromatin units, nucleosomes, are arranged into solenoids which form chromatin loops. To …

The last years have witnessed rapid progress in our understanding of chromatin structure at
the nucleosome or beads-on-a-string level (Elgin and Weintraub 1975; Kornberg 1977) …

Both intact and nuclease-isolated chromatin fibers have been examined at different degrees
of salt-induced compaction, using a variety of preparation techniques. The results suggest …

Electron micrographs of thin sections of metaphase chromosomes isolated from HeLa ceils
provide new insight into the higher-order arrangement of the nucleoprotein fiber …

We determined the folding of chromosomes in interphase nuclei by measuring the distance
between points on the same chromosome. Over 25,000 measurements were made in G0/G1 …

Higher-order chromatin fibers (200--300 A in diameter) are reproducibly released from
nuclei after lysis in the absence of formalin and/or detergent. Electron microscope analysis …

The question as to how the strands of chromatin are packed into the eukaryotic nucleus has
intrigued biologists and biochemists for many years. Although there is ample space in the …

Chromatin fragments, prepared by brief digestion with DNase II or micrococcal nuclease,
separated into a family of bands on sucrose gradients. The slowest migrating band with an S …

Unique roles have been identified for the histone octamer in the formation and stabilization
of higher order chromatin structures. Histone octamers were assembled onto 12 tandem …

The idea that DNA in chromatin can be packed smoothly, without breaking of base-stacking
interactions, has been explored by both energetical estimations and stereochemical model …