Oxygen Transport by a Pyridoxalated-Hemoglobin-Polyoxyethyle... : ASAIO Journal Oxygen
Transport by a Pyridoxalated-Hemoglobin-Polyoxyethylene Conjugate : ASAIO Journal Log in …

Polymerized pyridoxylated hemoglobin provides a means of obtaining an acellular oxygen
carrier that can be infused at a normal hemoglobin concentration, with a normal COP and is …

Polymerization of pyridoxylated stroma free hemoglobin (poly SFH-P) yields a solution with
a normal hemoglobin concentration, normal colloid osmotic pressure (COP), and a suitable …

The development of haemoglobin based oxygen carriers is intended to avoid the problems
which can arise from the use of blood. Blood can only be stored for a short period of time …

Problems associated with specific physiological properties of Hb-based blood substitutes,
such as a low P50, short plasma half-life and nephrotoxicity are still major issues to be …

A pyridoxalated hemoglobin‐polyoxyethylene conjugate (PHP) is an oxygen carrier
prepared from outdated human red cells through chemical modifications of hemoglobin …

PHP, mean molecular weight of approximately 90,000 daltons, is produced by chemical
modifications of outdated human red cell hemoglobin (Hb). The P50 value of PHP is 22±0.7 …

Chemically modified hemoglobins can be used as oxygen carriers in cell-free fluids
provided that they have a low oxygen affinity and are stable towards dissociation into …

The usefulness of hemoglobin solutions as oxygen transporters is limited by their high
affinity for oxygen and rapid elimination from the circulation. Various chemical modifications …

There are many situations where a quick substitution of erythrocytes is warranted. However
the need for blood typing generally causes considerable delay in getting the matched …