Jiang Tang Xiao Ke Granule Protects Hepatic Tissue of Diabetic Mice Through Modulation of Insulin and Ras Signaling–A Bioinformatics Analysis of MicroRNAs and …

Y Bai, X Bao, G Jiang, D Ge, W He, D Zhao… - Frontiers in …, 2020 - frontiersin.org
Objective To investigate the impact of JTXK granule on the miRNA expression profiles in
hepatic tissue of diabetic mice, and to explore the molecular targets and associated …

Jiang Tang Xiao Ke granule play an anti-diabetic role in diabetic mice pancreatic tissue by regulating the mRNAs and microRNAs associated with PI3K-Akt signaling …

FF Mo, T An, ZJ Zhang, YF Liu, HX Liu… - Frontiers in …, 2017 - frontiersin.org
Purpose: To investigate the effect of JTXK granule on the expression pattern of miRNA in
pancreatic tissue of KKAy diabetic mice, and to explore the molecular mechanism and …

Network Pharmacology-Based Strategy to Explore the Effect and Mechanism of Zhizhu Granule Improving Glucose-Lipid Metabolism in Rats with Metabolic Syndrome

J Wang, Y Liu, C Xiu, X Wang, Y Liu, Y Hu… - Diabetes, Metabolic …, 2024 - Taylor & Francis
Objective To explore the mechanism of the traditional Chinese medicine (TCM), Zhizhu
granule (ZZG), in treating metabolic syndrome (MS) based on network pharmacology and …

[HTML][HTML] Jiangtang Xiaoke granule attenuates glucose metabolism disorder via regulating endoplasmic reticulum stress in the liver of type 2 diabetes mellitus mice

Z Yi, M Fangfang, Z Dongwei, G Sihua… - Journal of Traditional …, 2018 - Elsevier
OBJECTIVE To observe the effect of Jiangtang Xiaoke (JTXK) granule on endoplasmic
reticulum (ER) stress in high fat diet (HFD)-induced type 2 diabetes mellitus (T2DM) KK-Ay …

[HTML][HTML] Bioinformatic analysis and construction of competitive endogenous RNA network reveals protective effect of Jiangtang Sanhao Formula on the liver of diabetic …

F Mo, T An, N Yang, D Zhao, D Zhang, G Jiang… - Pharmacological …, 2024 - Elsevier
Abstract Introduction Jiangtang Sanhao Formula (JTSHF), composed of Panax ginseng,
Atractylodes macrocephala, Coptis chinensis, Salvia miltiorrhiza and several other herbs, is …

[HTML][HTML] Qiyu Granules ameliorate insulin resistance via modulating PI3K/AKT/FoxO1 pathway and AMPK/PPARγ pathway in diabetic KKAy mice

FAN Xiaoxu, LIU Jiaqi, HUA Jian, W Zhen… - Chinese Journal of …, 2025 - Elsevier
Objective To investigate the protective effect and mechanism of Qiyu Granules in alleviating
insulin resistance in KKAy mice. Methods The chemical ingredients of Qiyu Granules were …

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

X Li, X Li, G Wang, Y Xu, Y Wang, R Hao, X Ma - Frontiers of Medicine, 2018 - Springer
Abstract Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes
mellitus (T2DM) for 10 years in Chinese traditional medication. However, its mechanisms …

[HTML][HTML] Yishen Huashi granule modulated lipid metabolism in diabetic nephropathy via PI3K/AKT/mTOR signaling pathways

T Zhao, Q Xiang, B Lie, D Chen, M Li, X Zhang, J Yang… - Heliyon, 2023 - cell.com
Aim Diabetic nephropathy (DN) is the primary cause of end-stage renal disease worldwide.
Although etiology for DN is complex and still needs to be fully understood, lipid metabolism …

Analysis of Mechanism of Yishen Huashi Granules for Improving Diabetic Nephropathy Based on Metabonomics and Transcriptomics

Z SHEN, T CUI, S AI, X LI, R GAO… - Chinese Journal of …, 2023 - pesquisa.bvsalud.org
ObjectiveIn this study, based on ultra-high performance liquid chromatography-mass
spectrometry (UHPLC-MS/MS) and high-throughput transcriptome sequencing technology …

Revealing the mechanism of huazhi rougan granule in the treatment of nonalcoholic fatty liver through intestinal flora based on 16S rRNA, metagenomic sequencing …

Y Liu, Y Tan, J Huang, C Wu, X Fan, A Stalin… - Frontiers in …, 2022 - frontiersin.org
Background: The incidence of Nonalcoholic Fatty Liver (NAFL) is increasing year by year,
growing evidence suggests that the intestinal flora plays a causative role in NAFL. Huazhi …