Controlled release of diphosphonates from synthetic polymers to inhibit calcification

G Golomb - Journal of biomaterials applications, 1987 - journals.sagepub.com
Calcification is the most frequent cause of the failure of bioprosthetic heart valves fabricated
from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. Formulation and …

Controlled release of diphosphonate to inhibit bioprosthetic heart valve calcification: dose-response and mechanistic studies

G Golomb, R Langer, FJ Schoen, MS Smith… - Journal of controlled …, 1986 - Elsevier
Calcification is the Principal cause of the clinical faliure of bioprosthetic heart valves (BHV)
fabricated from glutaraldehy de-treated porcine valves or bovine pericardium. This study …

Controlled release of ethanehydroxy diphosphonate from polyurethane reservoirs to inhibit calcification of bovine pericardium used in bioprosthetic heart valves

TP Johnston, JA Boyd, BL Ciesliga, FJ Schoen… - International journal of …, 1990 - Elsevier
Calcification (CALC) of bioprosthetic heart valves (BHVs) fabricated from either
glutaraldehyde-pretreated bovine pericardial tissue or porcine aortic valves is the most …

Controlled-release drug delivery of diphosphonates to inhibit bioprosthetic heart valve calcification: release rate modulation with silicone matrices via drug solubility …

G Golomb, M Dixon, MS Smith, FJ Schoen… - Journal of …, 1987 - Elsevier
Calcification (CALC) is the most frequent cause of the clinical failure of bioprosthetic heart
valves (BHV) fabricated from glutaraldehyde pretreated porcine aortic valves or bovine …

Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate

RJ Levy, J Wolfrum, FJ Schoen, MA Hawley, SA Lund… - Science, 1985 - science.org
Bioprostheses fabricated from porcine aortic valves are widely used to replace diseased
heart valves. Calcification is the principal cause of the clinical failure of these devices. In the …

Prevention of calcification of bioprosthetic heart valve leaflets by Ca2+ diphosphonate pretreatment

TP Johnston, FJ Schoen, RJ Levy - Journal of pharmaceutical …, 1988 - Wiley Online Library
Calcification frequently causes failure of bioprosthetic heart valves (BHV) fabricated from
glutaraldehyde‐pretreated porcine aortic valve or bovine pericardium. Systemic …

LOCAL CONTROLLED–RELEASE OF DIPHOSPHONATES FROM ETHYLENEVINYLACETATE MATRICES PREVENTS BIOPROSTHETIC HEART VALVE …

RJ Levy, G Golomb, J Wolfrum, SA Lund… - ASAIO …, 1985 - journals.lww.com
MATERIALS AND METHODS Chemicals and Supplies. Glutaraldehyde was obtained as an
8% aqueous solution from Polysciences (Warrington, PA). Ethylene vinylacetate (EVA)(40 …

Scanning electron microscopy studies of the prevention of bioprosthetic heart valve calcification with controlled release polymeric matrices

YV Pathak, J Boyd, TP Johnston, JT Levy… - Cells and …, 1991 - digitalcommons.usu.edu
Pathologic calcification is the principal failure mode of bioprosthetic heart valves fabricated
from glutaraldehyde pretreated porcine aortic valves. Bovine pericardial bioprosthetic valves …

Prevention of calcification of glutaraldehyde pretreated bovine pericardium through controlled release polymeric implants: studies of Fe3+, Al3+, protamine sulphate …

YV Pathak, J Boyd, RJ Levy, FJ Schoen - Biomaterials, 1990 - Elsevier
Calcification is the principal cause of the clinical failure of bioprosthetic heart valves
fabricated from glutaraldehyde pretreated porcine aortic valves or bovine pericardium. The …

Controlled release of 1-hydroxyethylidene diphosphonate: in vitro assessment and effects on bioprosthetic calcification in sheep tricuspid valve replacements

TP Johnston, EL Bove, SF Bolling, JA Boyd… - International journal of …, 1989 - Elsevier
Calcification (CALC) is the most frequent cause of the clinical failure of bioprosthetic valves
(BHV's). Controlled-release (paravalvar) administration of the anticalcification agent …