[HTML][HTML] The role of reactive oxygen species in bone cell physiology and pathophysiology

A Marques-Carvalho, HN Kim, M Almeida - Bone Reports, 2023 - Elsevier
Abstract Hydrogen peroxide (H 2 O 2), superoxide anion radical (O 2− radical dot), and other
forms of reactive oxygen species (ROS) are produced by the vast majority of mammalian …

Oxidative stress, free radicals and bone remodeling

G Banfi, EL Iorio, MM Corsi - Clinical chemistry and laboratory …, 2008 - degruyter.com
Reactive oxygen species (ROS) are widely considered to be a causal factor in aging and in
a number of pathological conditions, such as atherosclerosis, carcinogenesis and infarction …

Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases

DA Callaway, JX Jiang - Journal of bone and mineral metabolism, 2015 - Springer
Osteoclasts are cells derived from bone marrow macrophages and are important in
regulating bone resorption during bone homeostasis. Understanding what drives osteoclast …

Reactive oxygen species in osteoclast differentiation and possible pharmaceutical targets of ROS-mediated osteoclast diseases

TS Agidigbi, C Kim - International journal of molecular sciences, 2019 - mdpi.com
Reactive oxygen species (ROS) and free radicals are essential for transmission of cell
signals and other physiological functions. However, excessive amounts of ROS can cause …

Reactive oxygen species and exercise on bone metabolism: friend or enemy?

E Filaire, H Toumi - Joint Bone Spine, 2012 - Elsevier
Reactive oxygen species (ROS) are well recognised for playing a dual role as both
deleterious and beneficial species. They are normally generated by tightly regulated …

ROS signaling cascades: dual regulations for osteoclast and osteoblast

H Tao, G Ge, X Liang, W Zhang, H Sun… - Acta Biochimica et …, 2020 - academic.oup.com
Accumulating evidence indicates that intracellular reactive oxygen species (ROS)
production is highly involved in bone homeostasis by intervening osteoclast or osteoblast …

NADPH oxidases in bone homeostasis and osteoporosis

K Schröder - Cellular and Molecular Life Sciences, 2015 - Springer
Bone formation and degradation are perfectly coordinated. In case of an imbalance of these
processes diseases occur associated with exaggerated formation of new bone or bone loss …

Hydrogen peroxide, but not superoxide, stimulates bone resorption in mouse calvariae

JHE Fraser, MH Helfrich, HM Wallace, SH Ralston - Bone, 1996 - Elsevier
Reactive oxygen species such as superoxide and hydrogen peroxide have been implicated
as regulatory factors in the control of osteoclastic bone resorption. While superoxide radicals …

Oxidative stress in bone remodelling and disease

F Wauquier, L Leotoing, V Coxam, J Guicheux… - Trends in molecular …, 2009 - cell.com
Oxidative stress is characterised by an increased level of reactive oxygen species (ROS)
that disrupts the intracellular reduction–oxidation (redox) balance. Although initially shown …

Association of oxidative stress with postmenopausal osteoporosis and the effects of hydrogen peroxide on osteoclast formation in human bone marrow cell cultures

KH Baek, KW Oh, WY Lee, SS Lee, MK Kim… - Calcified tissue …, 2010 - Springer
It has been suggested that oxidative stress is associated with the pathogenesis of
osteoporosis. The objective of this study was to explore the association between a marker of …