Inhibition of JAK1/2 tyrosine kinases reduces neurogenic heterotopic ossification after spinal cord injury

KA Alexander, HW Tseng, W Fleming, B Jose… - Frontiers in …, 2019 - frontiersin.org
Neurogenic heterotopic ossifications (NHO) are very incapacitating complications of
traumatic brain and spinal cord injuries (SCI) which manifest as abnormal formation of bone …

Interleukin‐1 is overexpressed in injured muscles following spinal cord injury and promotes neurogenic heterotopic ossification

HW Tseng, I Kulina, D Girard, J Gueguen… - Journal of Bone and …, 2020 - academic.oup.com
Neurogenic heterotopic ossifications (NHOs) form in periarticular muscles after severe
spinal cord (SCI) and traumatic brain injuries. The pathogenesis of NHO is poorly …

Neurological heterotopic ossification following spinal cord injury is triggered by macrophage‐mediated inflammation in muscle

F Genêt, I Kulina, C Vaquette, F Torossian… - The Journal of …, 2015 - Wiley Online Library
Neurological heterotopic ossification (NHO) is the abnormal formation of bone in soft tissues
as a consequence of spinal cord or traumatic brain injury. NHO causes pain, ankyloses …

Lymphocytes are not required for neurogenic heterotopic ossification development after spinal cord injury

KA Alexander, HW Tseng, I Kulina, W Fleming… - Neurotrauma …, 2022 - liebertpub.com
Neurogenic heterotopic ossifications (NHOs) are incapacitating complications of traumatic
brain and spinal cord injuries (SCI) that manifest as abnormal bone formation in periarticular …

When the nervous system turns skeletal muscles into bones: how to solve the conundrum of neurogenic heterotopic ossification

KA Alexander, HW Tseng, M Salga, F Genêt… - Current osteoporosis …, 2020 - Springer
Abstract Purpose of Review Neurogenic heterotopic ossification (NHO) is the abnormal
formation of extra-skeletal bones in periarticular muscles after damage to the central …

[HTML][HTML] Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications

F Torossian, B Guerton, A Anginot, KA Alexander… - JCI insight, 2017 - ncbi.nlm.nih.gov
Neurogenic heterotopic ossification (NHO) is the formation of ectopic bone generally in
muscles surrounding joints following spinal cord or brain injury. We investigated the …

Bacterial lipopolysaccharides exacerbate neurogenic heterotopic ossification development

M Salga, SG Samuel, HW Tseng, L Gatin… - Journal of Bone and …, 2023 - academic.oup.com
Neurogenic heterotopic ossifications (NHO) are heterotopic bones that develop in
periarticular muscles after severe central nervous system (CNS) injuries. Several …

CGRP accelerates the pathogenesis of neurological heterotopic ossification following spinal cord injury

X Sang, Z Wang, P Shi, Y Li… - … Cells, Nanomedicine, and …, 2019 - Taylor & Francis
Background Interactions between the heterotopic ossification (HO) and the neurological
injuries have got lots of interest but still poorly understood. The present study aims to …

Peripheral denervation participates in heterotopic ossification in a spinal cord injury model

C Debaud, M Salga, L Begot, X Holy, M Chedik… - PloS one, 2017 - journals.plos.org
We previously reported the development of a new acquired neurogenic HO (NHO) mouse
model, combining spinal cord transection (SCI) and chemical muscle injury. Pathological …

Local and systemic factors drive ectopic osteogenesis in regenerating muscles of spinal-cord–injured mice in a lesion-level–dependent manner

C Debaud, HW Tseng, M Chedik, I Kulina… - Journal of …, 2021 - liebertpub.com
Neuroimmune dysfunction is thought to promote the development of several acute and
chronic complications in spinal cord injury (SCI) patients. Putative roles for adrenal stress …