Tissue factor activity is increased in a combined platelet and microparticle sample from cancer patients

RE Tilley, T Holscher, R Belani, J Nieva… - Thrombosis research, 2008 - Elsevier
BACKGROUND: Cancer patients have an increased risk of thrombosis. Tissue factor (TF)
antigen and TF activity associated with microparticles in plasma are elevated in patients with …

Microparticle-associated tissue factor activity in cancer patients with and without thrombosis

MET Tesselaar, F Romijn, IK Van Der Linden… - Journal of Thrombosis …, 2009 - jthjournal.org
In a previous study [1], we found that the tissue factor (TF) activity of microparticles (MP)
isolated from platelet-poor plasma (MP-TF activity) was markedly increased in patients with …

Increased microparticle tissue factor activity in cancer patients with venous thromboembolism

DA Manly, J Wang, SL Glover, R Kasthuri… - Thrombosis research, 2010 - Elsevier
Cancer patients exhibit a high rate of thromboembolism (VTE). In this study, we analyzed
levels of microparticle (MP) tissue factor (TF) activity in cancer patients with or without VTE …

Tissue factor expressed by microparticles is associated with mortality but not with thrombosis in cancer patients

C Hernández, J Orbe, C Roncal… - Thrombosis and …, 2013 - thieme-connect.com
A prothrombotic state is one of the hallmarks of malignancy and a major contributor to
morbidity and mortality in cancer patients. Tissue factor (TF) is often overexpressed in …

Pre-analytical and analytical variables affecting the measurement of plasma-derived microparticle tissue factor activity

RD Lee, DA Barcel, JC Williams, JG Wang, JC Boles… - Thrombosis research, 2012 - Elsevier
INTRODUCTION: Elevated levels of tissue factor positive (TF+) microparticles (MPs) are
observed in plasma from a variety of patients with an increased risk of thrombosis. We and …

Tumor-derived tissue factor–positive microparticles and venous thrombosis in cancer patients

JE Geddings, N Mackman - Blood, The Journal of the American …, 2013 - ashpublications.org
Patients with cancer have an increased risk for venous thrombosis. Interestingly, different
cancer types have different rates of thrombosis, with pancreatic cancer having one of the …

Tissue factor-positive microparticles in blood associated with coagulopathy in cancer

U Rauch, S Antoniak - Thrombosis and haemostasis, 2007 - thieme-connect.com
T hrombotic events are the major complication in cancer patients, which contribute
significantly to the patients' morbidity and mortality. Upregulation of tissue factor (TF), the …

[HTML][HTML] Microparticle‐associated tissue factor activity, venous thromboembolism and mortality in pancreatic, gastric, colorectal and brain cancer patients

J THALER, C Ay, N Mackman, RM Bertina… - Journal of Thrombosis …, 2012 - Elsevier
Background: Tissue factor (TF) expression by tumors contributes to tumor growth. Release of
TF‐positive microparticles (MPs) may contribute to venous thromboembolism (VTE) …

Tissue factor procoagulant activity of plasma microparticles is increased in patients with early-stage prostate cancer

K Haubold, M Rink, B Spath, M Friedrich… - Thrombosis and …, 2009 - thieme-connect.com
Tissue factor (TF) plays a critical role in tumour growth and metastasis, and its enhanced
release into plasma in association with cellular microparticles (MPs) has recently been …

Tissue factor-positive microparticles: cellular origin and association with coagulation activation in patients with colorectal cancer

G Hron, M Kollars, H Weber, V Sagaster… - Thrombosis and …, 2007 - thieme-connect.com
The pathogenesis of hypercoagulability in cancer is not entirely understood. We
hypothesized that in cancer patients circulating tissue factor-positive microparticles (TF+ …