A parts list for fungal cellulosomes revealed by comparative genomics

CH Haitjema, SP Gilmore, JK Henske… - Nature …, 2017 - nature.com
Cellulosomes are large, multiprotein complexes that tether plant biomass-degrading
enzymes together for improved hydrolysis 1. These complexes were first described in …

The cellulosomes: multienzyme machines for degradation of plant cell wall polysaccharides

EA Bayer, JP Belaich, Y Shoham… - Annu. Rev. Microbiol …, 2004 - annualreviews.org
▪ Abstract The discrete multicomponent, multienzyme cellulosome complex of anaerobic
cellulolytic bacteria provides enhanced synergistic activity among the different resident …

Cellulosome assembly revealed by the crystal structure of the cohesin–dockerin complex

AL Carvalho, FMV Dias, JAM Prates… - Proceedings of the …, 2003 - National Acad Sciences
The utilization of organized supramolecular assemblies to exploit the synergistic interactions
afforded by close proximity, both for enzymatic synthesis and for the degradation of …

Genome-wide analysis of Acetivibrio cellulolyticus provides a blueprint of an elaborate cellulosome system

B Dassa, I Borovok, R Lamed, B Henrissat, P Coutinho… - BMC genomics, 2012 - Springer
Background Microbial degradation of plant cell walls and its conversion to sugars and other
byproducts is a key step in the carbon cycle on Earth. In order to process heterogeneous …

Transcriptomic characterization of Caecomyces churrovis: a novel, non-rhizoid-forming lignocellulolytic anaerobic fungus

JK Henske, SP Gilmore, D Knop… - Biotechnology for …, 2017 - Springer
Anaerobic gut fungi are the primary colonizers of plant material in the rumen microbiome,
but are poorly studied due to a lack of characterized isolates. While most genera of gut fungi …

Cellulosomes: microbial nanomachines that display plasticity in quaternary structure

HJ Gilbert - Molecular microbiology, 2007 - Wiley Online Library
The assembly of proteins that display complementary activities into supramolecular intra‐
and extracellular complexes is central to cellular function. One such nanomachine of …

Cellulosomes: bacterial nanomachines for dismantling plant polysaccharides

L Artzi, EA Bayer, S Moraïs - Nature Reviews Microbiology, 2017 - nature.com
Cellulosomes are multienzyme complexes that are produced by anaerobic cellulolytic
bacteria for the degradation of lignocellulosic biomass. They comprise a complex of …

Insights into cellulosome assembly and dynamics: from dissection to reconstruction of the supramolecular enzyme complex

SP Smith, EA Bayer - Current Opinion in Structural Biology, 2013 - Elsevier
Highlights•Cellulosomes are highly efficient plant cell wall polysaccharide-degrading
enzyme complexes.•New structures of cohesin–dockerin complexes show single mode type …

Transcriptomic analysis of lignocellulosic biomass degradation by the anaerobic fungal isolate Orpinomyces sp. strain C1A

MB Couger, NH Youssef, CG Struchtemeyer… - Biotechnology for …, 2015 - Springer
Background Anaerobic fungi reside in the rumen and alimentary tract of herbivores where
they play an important role in the digestion of ingested plant biomass. The anaerobic fungal …

Designing chimeric enzymes inspired by fungal cellulosomes

SP Gilmore, SP Lillington, CH Haitjema… - Synthetic and Systems …, 2020 - Elsevier
Cellulosomes are synthesized by anaerobic bacteria and fungi to degrade lignocellulose via
synergistic action of multiple enzymes fused to a protein scaffold. Through templating key …