Previously, authors have reviewed the evidence pertaining to a wide range of
neurochemical, neuroendocrine, neurophysiological, and structural correlates of …

Recent studies have begun to characterize the actions of stress and antidepressant
treatments beyond the neurotransmitter and receptor level. This work has demonstrated that …

The neurogenesis hypothesis of depression was originally formed upon the demonstration
that stress impacts levels of adult neurogenesis in the hippocampus. Since then much work …

The molecular neurobiology of depression begins with the concept that depressive
disorders represent a family of related but distinct conditions. Different points of vulnerability …

Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …

Elucidation of the neurobiological basis of depression and other mood disorders is rapidly
increasing. Considerable experimental and clinical evidence supports the fundamental roles …

Depression is one of the leading causes of disability, and, if left unmanaged, it can increase
the risk for suicide. The evidence base on the determinants of depression is fragmented …

Thousands of studies have been conducted of the functioning of the many neurotransmitter
systems in order to explore the biologic basis of major depressive disorder. Instead of …

This book presents a way of organizing evidence from many diverse disciplines, and it
shows that much of what has been uncovered empirically about the psychobiology of …

A number of factors (biogenic amine deficiency, genetic, environmental, immunologic,
endocrine factors and neurogenesis) have been identified as mechanisms which provide …