Systematic review and meta-analysis of genetic studies of late-life depression
Late-life depression (LLD) is thought to be multifactorial in etiology, including a significant
genetic component. While a number of candidate gene studies have been carried out …
genetic component. While a number of candidate gene studies have been carried out …
Social determinants of late-life depression epigenetics
M Lozupone, F Panza - Epigenomics, 2020 - Taylor & Francis
Late-life depression (LLD) is a frequent disorder in later years of life with an age of onset
ranging from 45 to 65 years [1]. LLD can be subdivided in late-onset and early-onset …
ranging from 45 to 65 years [1]. LLD can be subdivided in late-onset and early-onset …
Genetic evidence supporting a causal role of depression in Alzheimer's disease
Background Depression has been associated with a higher risk of Alzheimer's disease (AD)
in several prospective studies; however, mechanisms underlying this association remain …
in several prospective studies; however, mechanisms underlying this association remain …
Characterizing heterogeneity in neuroimaging, cognition, clinical symptoms, and genetics among patients with late-life depression
Importance Late-life depression (LLD) is characterized by considerable heterogeneity in
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …
clinical manifestation. Unraveling such heterogeneity might aid in elucidating etiological …
Genome-wide screen to identify genetic loci associated with cognitive decline in late-life depression
DC Steffens, ME Garrett, KL Soldano… - International …, 2024 - cambridge.org
Objective: This study sought to conduct a comprehensive search for genetic risk of cognitive
decline in the context of geriatric depression. Design: A genome-wide association study …
decline in the context of geriatric depression. Design: A genome-wide association study …
Genetic heterogeneity in depressive symptoms following the death of a spouse: Polygenic score analysis of the US Health and Retirement Study
Objective: Experience of stressful life events is associated with risk of depression. Yet many
exposed individuals do not become depressed. A controversial hypothesis is that genetic …
exposed individuals do not become depressed. A controversial hypothesis is that genetic …
Development of risk prediction models for depression combining genetic and early life risk factors
Background Both genetic and early life risk factors play important roles in the pathogenesis
and progression of adult depression. However, the interplay between these risk factors and …
and progression of adult depression. However, the interplay between these risk factors and …
Multivariate genome-wide association study of depression, cognition, and memory phenotypes and validation analysis identify 12 cross-ethnic variants
J Sun, W Wang, R Zhang, H Duan, X Tian, C Xu… - Translational …, 2022 - nature.com
To date, little is known about the pleiotropic genetic variants among depression, cognition,
and memory. The current research aimed to identify the potential pleiotropic single …
and memory. The current research aimed to identify the potential pleiotropic single …
Shared genetic risk factors for late-life depression and Alzheimer's disease
Q Ye, F Bai, Z Zhang - Journal of Alzheimer's Disease, 2016 - content.iospress.com
Background: Considerable evidence has been reported for the comorbidity between late-life
depression (LLD) and Alzheimer's disease (AD), both of which are very common in the …
depression (LLD) and Alzheimer's disease (AD), both of which are very common in the …
Age-by-disease biological interactions: implications for late-life depression
Onset of depressive symptoms after the age of 65, or late-life depression (LLD), is common
and poses a significant burden on affected individuals, caretakers, and society. Evidence …
and poses a significant burden on affected individuals, caretakers, and society. Evidence …