An increasing body of data implicates the Septin family in the pathology of several diseases,
including male fertility. The objective of this study was to evaluate the gene and protein …

Background: Septins are an evolutionary conserved group of GTP-binding and filament-
forming proteins that have diverse cellular roles. An increasing body of data implicates the …

Purpose To investigate the expression pattern of the SEPT7 protein during spermatogenesis
and its potential role in sperm function. Methods We first investigated the expression pattern …

Septins belong to a family of polymerizing GTP-binding proteins that are required for many
cellular functions, such as membrane compartmentalization, vesicular trafficking, mitosis …

Methods Samples of ejaculated sperm from idiopathic asthenozoospermia patients and
normozoospermic men were separated and purified by Percoll discontinuous density …

Background: Male infertility is a multifactorial disorder, which affects approximately 10% of
couples at childbearing age with substantial clinical and social impact. Genetic factors are …

Background and aims Motility and morphological defects of spermatozoa can cause male
infertility. Sperm RNAs are related to sperm quality. They are considered to have clinical …

Purpose: Septins are the major constituents of the annulus, a submembranous ring that
separates the middle and principal pieces of spermatozoa. We previously reported its …

SEPT12 is a testis‐specific gene involved in the terminal differentiation of male germ cells.
SEPT12 protein is required for sperm head‐tail formation and acts as a fundamental …

Genetic mechanisms have been implicated as a cause of some cases of male infertility.
Recently, 10 novel genes involved in human spermatogenesis, including human SEPTIN12 …