Podocytes are specialized actin-rich epithelial cells that line the kidney glomerular filtration
barrier. The interface between the podocyte and the glomerular basement membrane …

Podocytes are specialized actin-rich epithelial cells that line the kidney glomerular filtration
barrier. The interface between the podocyte and the glomerular basement membrane …

Podocyte foot processes (FPs) and their interposed slit diaphragm (SD) are key components
of the permeability barrier in the glomerulus. Damage of podocytes (FP effacement) result in …

Background The hallmark of podocytopathies, such as FSGS, is podocyte injury resulting in
proteinuria. Transient receptor potential channel C6 (TRPC6) is a calcium-conducting ion …

Integrins are αβ heterodimeric cell-adhesion molecules that support many biological
processes, such as neutrophil-mediated tissue injury in inflammatory disorders. New data …

Abstract Background and Aims Cell-matrix adhesion molecules in podocytes play a critical
role in attaching these cells to the glomerular basement membrane, ensuring the proper …

Background Patients with certain mutations in the gene encoding the slit diaphragm protein
Nephrin fail to develop functional slit diaphragms and display severe proteinuria. Many adult …

Kidney collecting system development requires integrin-dependent cell-extracellular matrix
interactions. Integrins are heterodimeric transmembrane receptors consisting of α and β …

Background: Focal adhesion proteins in podocytes are critical for attaching to the glomerular
basement membrane. Reduction in these proteins causes podocyturia, frequently observed …

Podocytes are epithelial cells that line the outer aspect of renal blood vessels and provide a
platform for the kidney's filtering apparatus, the slit diaphragm. Mutations in α‐actinin‐4, an …