FLT3 is a receptor tyrosine kinase expressed by immature hematopoietic cells and is
important for the normal development of stem cells and the immune system. The ligand for …

FLT3, a member of the receptor tyrosine kinase (RTK) class III, is preferentially expressed on
the surface of a high proportion of acute myeloid leukemia (AML) and B-lineage acute …

FLT3 is a receptor tyrosine kinase of 130-155 kDa expresssed on normal bone marrow stem
and early progenitor cells and on leukemic blasts from patients with acute leukemias. The …

FLT3 is the most frequently mutated gene in cases of acute myelogenous leukemia (AML).
About 30 to 35% of patients have either internal tandem duplications (ITDs) in the …

Mutations of receptor tyrosine kinases are implicated in the constitutive activation and
development of human malignancy. An internal tandem duplication (ITD) of the …

Activating mutations of FLT3 have been detected in patients with acute myeloid leukemia
(AML). Two distinct types of FLT3 mutations are most common: internal tandem duplication …

FLT3 receptor tyrosine kinase is expressed on lymphoid and myeloid progenitors in the
hematopoietic system. Activating mutations in FLT3 have been identified in approximately …

FLT3, a member of the class III receptor tyrosine kinases (RTKs), is preferentially expressed
on the cell surface of hematopoietic progenitors, and the ligand of FLT3 (FL) is expressed as …

The cytokine Fms-like tyrosine kinase 3 ligand (FL) is an important regulator of
hematopoiesis. Its receptor, Flt3, is expressed on myeloid, lymphoid and dendritic cell …

The FLT3 receptor is activated by juxtamembrane insertion mutations and by activation loop
point mutations in patients with acute myeloid leukemia (AML). In a systematic tyrosine …