Extracellular site of action of phenylalkylamines on L-type calcium current in rat ventricular myocytes

JW Wegener, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1995 - Springer
The effects of the phenylalkylamines verapamil, gallopamil, and devapamil on L-type
calcium currents (I Ca) were studied in ventricular myocytes from rat hearts using the whole …

Kinetics and state-dependent effects of verapamil on cardiac L-type calcium channels

H Nawrath, JW Wegener - Naunyn-Schmiedeberg's archives of …, 1996 - Springer
The voltage dependence and the kinetics of block by verapamil of L-type calcium current (I
Ca) were investigated in ventricular myocytes from rat hearts using the whole-cell patch …

Selectivity of different calcium antagonists on T-and L-type calcium currents in guinea-pig ventricular myocytes

P De Paoli, E Cerbai, B Koidl, M Kirchengast… - Pharmacological …, 2002 - Elsevier
Both L-and T-type calcium channels are present in the heart. In cardiac myocytes L-type
calcium channels are blocked by the classical calcium channel blockers, while T-type …

Effects of PDE inhibitors and carbachol on the L-type Ca current in guinea pig ventricular myocytes

K Mubagwa, T Shirayama, M Moreau… - American Journal of …, 1993 - journals.physiology.org
The phosphodiesterase inhibitors 3-isobutyl-1-methylxanthine (IBMX; 100 microM) and
papaverine (100 microM) increased peak L-type Ca current (ICa) more than fivefold in a way …

A novel benzothiazine Ca2+ channel antagonist, semotiadil, inhibits cardiac L-type Ca2+ currents

B Koidl, N Miyawaki, HA Tritthart - European journal of pharmacology, 1997 - Elsevier
The influence of semotiadil fumarate, a novel vasoselective Ca2+ channel antagonist with a
benzothiazine skeleton, was measured on the high-threshold Ca2+ current ICa, L in guinea …

Multiple modulations of action potential duration by different calcium channel blocking agents in guinea pig ventricular myocytes

S Zhang, T Sawanobori, Y Hirano… - Journal of …, 1997 - journals.lww.com
Abstract Effects of extracellular applications of different types of Ca 2+ channel blocking
agents (Mn 2+, verapamil, and nisoldipine) on action-potential duration and membrane …

Action of tertiary phenylalkylamines on cardiac transient outward current from outside the cell membrane

JW Wegener, H Nawrath - Naunyn-Schmiedeberg's archives of …, 1996 - Springer
The effects of the phenylalkylamines verapamil (V), gallopamil (G), and devapamil (D) and
their corresponding quaternary derivatives on the transient outward current (I to) were …

Differential effects of verapamil and flunarizine on cardiac L-type and T-type Ca channels

J Tytgat, J Vereecke, E Carmeliet - Naunyn-Schmiedeberg's archives of …, 1988 - Springer
Whole cell experiments were used to study whether the L-type and the T-type Ca channel in
guinea-pig ventricular myocytes are blocked similarly by verapamil and flunarizine. The L …

Butanedione Monoxime Promotes Voltage-dependent Inactivation ofL-Type Calcium Channels in Heart. Effects on Gating Currents

G Ferreira, P Artigas, GPG Brum - Journal of molecular and cellular …, 1997 - Elsevier
The effect of 20 mmextracellularly applied 2, 3-Butanedione monoxime (BDM) onl-type
Ca2+ channel charge movement current was studied in whole-cell voltage-clamped guinea …

The calcium antagonist D600 inhibits calcium‐independent transient outward current in isolated rat ventricular myocytes.

IA Lefevre, A Coulombe… - The Journal of …, 1991 - Wiley Online Library
1. The whole‐cell voltage‐clamp technique was applied to isolated rat ventricular myocytes
to investigate the effects of D600 (10 (‐9)‐10 (‐3) M) on the intracellular calcium …