The idea that DNA in chromatin can be packed smoothly, without breaking of base-stacking
interactions, has been explored by both energetical estimations and stereochemical model …

The question as to how the strands of chromatin are packed into the eukaryotic nucleus has
intrigued biologists and biochemists for many years. Although there is ample space in the …

Each level of DNA folding in cells corresponds to a distinct chromatin structure. The basic
chromatin units, nucleosomes, are arranged into solenoids which form chromatin loops. To …

Linker DNA, which connects between nucleosomes in chromatin, is short and, therefore,
may be essentially straight and inflexible. We have carried out hydrodynamic and electron …

The" 30-nm" chromatin fibers, as observed in eukaryotic nuclei, are considered a discrete
level in a hierarchy of DNA folding. At present, there is considerable debate as to how the …

One of the critical unanswered questions in genome biophysics is how the primary
sequence of DNA bases influences the global properties of very-long-chain molecules. The …

The basic chromatin fiber is composed of a tandem array of nucleosomes, adjacement
nucleosomes being separated by a variable amount of DNA. In vivo, this fiber is folden to …

The DNA of a nucleosome core particle is wrapped tightly around a histone octamer with
approximately 80 base pairs per superhelical turn. Studies of both naturally occurring and …

Chromatin was assembled in vitro from relaxed closed circular DNA (SV40) and core
histones at histone to DNA ratios of 0.2 to 0.3 (g/g) and incubated with topoisomerase I to …

DNA supercoiling on the nucleosome was investigated by relaxing with topoisomerase I
mono-and dinucleosomes reconstituted on small DNA rings. Besides 359 base-pair (bp) …