Paradoxical relationship between the degree of EGFR amplification and outcome in glioblastomas

J Hobbs, MN Nikiforova, DW Fardo… - The American journal …, 2012 - journals.lww.com
Glioblastoma (GBM) is the most common primary brain tumor in adults and often has
amplification of the epidermal growth factor receptor (EGFR) gene. The value of EGFR as a …

Epidermal growth factor receptor gene amplification as a prognostic marker in glioblastoma multiforme: results of a meta-analysis.

M Huncharek, B Kupelnick - Oncology research, 2000 - europepmc.org
Amplification of the epidermal growth factor receptor (EGFR) gene occurs in approximately
40% of cases of glioblastoma multiforme (GBM) and is considered a possible marker of poor …

Contrasting in vivo and in vitro fates of glioblastoma cell subpopulations with amplified EGFR

A Pandita, KD Aldape, G Zadeh… - Genes …, 2004 - Wiley Online Library
Despite the high incidence of EGFR amplification in patient glioblastoma multiforme (GBM)
tissues, only a single GBM cell line, of the many described in the literature, is known to …

The natural history of EGFR and EGFRvIII in glioblastoma patients

AB Heimberger, D Suki, D Yang, W Shi… - Journal of translational …, 2005 - Springer
Background The epidermal growth factor receptor (EGFR) is over expressed in
approximately 50–60% of glioblastoma (GBM) tumors, and the most common EGFR mutant …

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme

N Shinojima, K Tada, S Shiraishi, T Kamiryo, M Kochi… - Cancer research, 2003 - AACR
Glioblastoma multiforme (GBM) frequently involves amplification and alteration of the
epidermal growth factor receptor (EGFR) gene, resulting in overexpression of varied …

Epidermal Growth Factor Receptor Variant III (EGFRvIII) Positivity in EGFR-Amplified Glioblastomas: Prognostic Role and Comparison between Primary and …

J Felsberg, B Hentschel, K Kaulich, D Gramatzki… - Clinical Cancer …, 2017 - AACR
Purpose: Approximately 40% of all glioblastomas have amplified the EGFR gene, and about
half of these tumors express the EGFRvIII variant. The prognostic role of EGFRvIII in EGFR …

Epidermal growth factor receptor gene amplification and protein expression in glioblastoma multiforme: prognostic significance and relationship to other prognostic …

LJ Layfield, C Willmore, S Tripp, C Jones… - Applied …, 2006 - journals.lww.com
Epidermal growth factor receptor (EGFR) overexpression occurs in a significant percentage
of cases of glioblastoma multiforme (GBM), and amplification has been found in …

Prognostic value of epidermal growth factor receptor amplification and EGFR v III in glioblastoma: meta‐analysis

JR Chen, HZ Xu, Y Yao, ZY Qin - Acta Neurologica …, 2015 - Wiley Online Library
Objectives Epidermal growth factor receptor (EGFR) gene amplification and the EGFR v III
mutation may have prognostic value in patients with glioblastoma. This meta‐analysis was …

Epidermal growth factor receptor amplification does not have prognostic significance in patients with glioblastoma multiforme

AL Quan, GH Barnett, SY Lee, MA Vogelbaum… - International Journal of …, 2005 - Elsevier
Purpose: There have been conflicting reports in the literature regarding the prognostic
significance of epidermal growth factor receptor (EGFR) amplification in patients with …

Determination of EGFR status in gliomas: usefulness of immunohistochemistry and fluorescent in situ hybridization

A Guillaudeau, K Durand, I Pommepuy… - Applied …, 2009 - journals.lww.com
Epidermal growth factor receptor (EGFR) is produced during the molecular pathogenesis of
glioma, and new anti-EGFR molecules are available for therapeutics. Consequently …