Targeting SHP2 as a promising strategy for cancer immunotherapy
Q Liu, J Qu, M Zhao, Q Xu, Y Sun - Pharmacological research, 2020 - Elsevier
Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a major phosphatase
involved in several cellular processes. In recent years, SHP2 has been the focus of …
involved in several cellular processes. In recent years, SHP2 has been the focus of …
[HTML][HTML] SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade
Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its
bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric …
bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric …
[HTML][HTML] Strategies to overcome drug resistance using SHP2 inhibitors
M Liu, S Gao, RM Elhassan, X Hou, H Fang - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Encoded by PTPN11, the SHP2 (Src homology-2 domain-containing protein tyrosine
phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti …
phosphatase-2) is widely recognized as a carcinogenic phosphatase. As a promising anti …
SHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms
SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune
cell signaling. In this study, we discovered a novel immune modulatory function of SHP2 …
cell signaling. In this study, we discovered a novel immune modulatory function of SHP2 …
Allosteric SHP2 inhibitors in cancer: Targeting the intersection of RAS, resistance, and the immune microenvironment
The nonreceptor protein tyrosine phosphatase SHP2 (encoded by PTPN11) integrates
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
growth and differentiation signals from receptor tyrosine kinases (RTKs) into the …
SHP-2 in lymphocytes' cytokine and inhibitory receptor signaling
C Niogret, W Birchmeier, G Guarda - Frontiers in immunology, 2019 - frontiersin.org
Somewhat counterintuitively, the tyrosine phosphatase SHP-2 (SH2 domain-containing
protein tyrosine phosphatase-2) is crucial for the activation of extracellular signal-regulated …
protein tyrosine phosphatase-2) is crucial for the activation of extracellular signal-regulated …
Allosteric inhibitors of SHP2 with therapeutic potential for cancer treatment
SHP2, a cytoplasmic protein-tyrosine phosphatase encoded by the PTPN11 gene, is
involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways …
involved in multiple cell signaling processes including Ras/MAPK and Hippo/YAP pathways …
Recent advances of SHP2 inhibitors in cancer therapy: current development and clinical application
X Yuan, H Bu, J Zhou, CY Yang… - Journal of medicinal …, 2020 - ACS Publications
SHP2 (Src homology-2 domain-containing protein tyrosine phosphatase-2) is a non-
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …
receptor protein tyrosine phosphatase that removes tyrosine phosphorylation. Functionally …
[HTML][HTML] Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies
Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy
target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As …
target for various diseases, serving as a well-known oncogenic phosphatase in cancers. As …
Allosteric inhibition of SHP2 stimulates antitumor immunity by transforming the immunosuppressive environment
E Quintana, CJ Schulze, DR Myers, TJ Choy, K Mordec… - Cancer research, 2020 - AACR
The protein tyrosine phosphatase SHP2 binds to phosphorylated signaling motifs on
regulatory immunoreceptors including PD-1, but its functional role in tumor immunity is …
regulatory immunoreceptors including PD-1, but its functional role in tumor immunity is …