The interaction of quinidine with a cloned human cardiac potassium channel (HK2)
expressed in a stable mouse L cell line was studied using the whole-cell tight-seal voltage …

The antiarrhythmic drug quinidine has been shown to block several types of K+ channel
currents in cardiac preparations including the transient outward current (Ito). To characterize …

1 The effects of quinidine on calcium‐independent outward K+ currents in rat ventricular
myocytes were studied using whole‐cell patch clamp techniques. 2 Quinidine sulphate (6 …

The modes in which quinidine blocks the delayed K current (1K) of rabbit sinoatrial and
atrioventricular nodes were investigated by voltage clamp experiments using small …

The electrophysiological properties of HK2 (Kv1. 5), a K+ channel cloned from human
ventricle, were investigated after stable expression in a mouse Ltk-cell line. Cell lines that …

ABSTRACT The effect of 4-aminopyridine (4-AP) on membrane and gating currents of Kv1. 5
channels was studied in a human cell line. The rank order of block was cell-attached> whole …

The molecular basis of antiarrhythmic drug action is still poorly understood. We recently
reported that block of the human cardiac hKv1. 5 channel by quinidine displayed similarity …

The antiarrhythmic agent quinidine blocks the human cardiac hKv1. 5 channel expressed in
mammalian cells at therapeutically relevant concentrations (EC50, 6.2 μmol/L). Mechanistic …

We studied quinidine block of Kv1. 4ΔN, a K+ channel lacking N‐type inactivation,
expressed in Xenopus ooctyes. Initially, quinidine intracellularly blocked the open channel …

4-aminopyridine (4AP) is widely used as a selective blocker of voltage-activated K+ currents
in excitable membranes, but its mechanism and site of action at the molecular level are not …