Abstract Changes in the morphology of human and murine chromosomes during the
different stages of mitosis have been examined by scanning electron microscopy. Two …

Human metaphase chromosomes, prepared for light microscopy, were examined by
scanning electron microscopy. Use of an osmium impregnation technique eliminated the …

New methods are presented for the bulk isolation of metaphase chromosomes from HeLa
cells, and an electron microscopic study of thin sections of these chromosomes is presented …

The development of procedures for the isolation of unfixed metaphase chromosomes has
made feasible a direct analysis of their morphology. Wholemount stereo electron microscopy …

Whole mount metaphase chromosomes, from cultured L cells, have been centrifuged onto
grids and examined by electron microscopy. Compact and dispersed chromosome forms …

Since 1968, when Comings published the pioneering paper [87] on “the rationale for an
ordered arrangement of chromatin in the interphase nucleus,” technical methods have …

Whole-mount electron microscopy of metaphase mouse L-cells showed that in many cases
the region of the centromere was located at one extreme end of the chromosome with no …

The arrangement of chromosomes in the interphase nucleus has intrigued scientists for over
a century. Chromosomes are best visualized as condensed mitotic structures which allow …

Scanning electron microscopy (SEM) was used to observe surface-spread, critical-point-
dried human interphase nuclei and chromosomes from cultures of peripheral lymphocytes …

Chromosomes from ten human male fibroblast metaphases were completely reconstructed
from electron micrographs of serially sectioned material. Chromosome centromere positions …