Identification of TGF-β receptor-1 as a key regulator of carbon nanotube-induced fibrogenesis

A Mishra, TA Stueckle, RR Mercer… - … of Physiology-Lung …, 2015 - journals.physiology.org
Carbon nanotubes (CNTs) induce rapid interstitial lung fibrosis, but the underlying
mechanisms are unclear. Previous studies indicated that the ability of CNTs to penetrate …

Multiwall carbon nanotubes mediate macrophage activation and promote pulmonary fibrosis through TGF‐β/Smad signaling pathway

P Wang, X Nie, Y Wang, Y Li, C Ge, L Zhang, L Wang… - Small, 2013 - Wiley Online Library
Multiwall carbon nanotubes (MWCNTs) have been widely used in many disciplines due to
their unique physical and chemical properties, but have also raised great concerns about …

Effect of fiber length on carbon nanotube-induced fibrogenesis

A Manke, S Luanpitpong, C Dong, L Wang… - International journal of …, 2014 - mdpi.com
Given their extremely small size and light weight, carbon nanotubes (CNTs) can be readily
inhaled by human lungs resulting in increased rates of pulmonary disorders, particularly …

Multiwall carbon nanotubes directly promote fibroblast–myofibroblast and epithelial–mesenchymal transitions through the activation of the TGF‐β/Smad signaling …

P Wang, Y Wang, X Nie, C Braïni, R Bai, C Chen - Small, 2015 - Wiley Online Library
A number of studies have demonstrated that MWCNTs induce granuloma formation and
fibrotic responses in vivo, and it has been recently reported that MWCNT‐induced …

Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 …

M Polimeni, GR Gulino, E Gazzano, J Kopecka… - Particle and fibre …, 2015 - Springer
Background Multi-walled carbon nanotubes (MWCNT) are currently under intense
toxicological investigation due to concern on their potential health effects. Current in vitro …

Single-walled carbon nanotube (SWCNT)-induced interstitial fibrosis in the lungs of rats is associated with increased levels of PDGF mRNA and the formation of …

JB Mangum, EA Turpin, A Antao-Menezes… - Particle and fibre …, 2006 - Springer
Background Nanotechnology is a rapidly advancing industry with many new products
already available to the public. Therefore, it is essential to gain an understanding of the …

Mediation of the single-walled carbon nanotubes induced pulmonary fibrogenic response by osteopontin and TGF-β1

TO Khaliullin, ER Kisin, AR Murray… - Experimental lung …, 2017 - Taylor & Francis
Purpose of the study: A number of in vivo studies have shown that pulmonary exposure to
carbon nanotubes (CNTs) may lead to an acute local inflammatory response, pulmonary …

Pulmonary toxicity and fibrogenic response of carbon nanotubes

A Manke, L Wang, Y Rojanasakul - Toxicology mechanisms and …, 2013 - Taylor & Francis
Carbon nanotubes (CNTs) have been a subject of intensive research for a wide range of
applications. However, because of their extremely small size and light weight, CNTs are …

Epithelial–mesenchymal transition involved in pulmonary fibrosis induced by multi-walled carbon nanotubes via TGF-beta/Smad signaling pathway

T Chen, H Nie, X Gao, J Yang, J Pu, Z Chen, X Cui… - Toxicology letters, 2014 - Elsevier
Multi-walled carbon nanotubes (MWCNT) are a typical nanomaterial with a wide spectrum of
commercial applications. Inhalation exposure to MWCNT has been linked with lung fibrosis …

Assessment of pulmonary fibrogenic potential of multiwalled carbon nanotubes in human lung cells

A Mishra, Y Rojanasakul, BT Chen… - Journal of …, 2012 - Wiley Online Library
Multiwalled carbon nanotubes have been shown to possess unusual fibrogenic activity in
vivo and are currently the focus of intense toxicological investigations. This study further …