Design, synthesis, cytotoxicity and molecular modeling studies of some novel fluorinated pyrazole-based heterocycles as anticancer and apoptosis-inducing agents
Diamino-4-(3-trifluoromethylphenyldiazenyl)-1 H-pyrazole was used as a starting scaffold for
the synthesis of new pyrazole-based heterocycles to study their effects on the proliferation of …
the synthesis of new pyrazole-based heterocycles to study their effects on the proliferation of …
Novel Pyrazole‐Based Benzofuran Derivatives as Anticancer Agents: Synthesis, Biological Evaluation, and Molecular Docking Investigations
I Ameziane El Hassani, A Altay… - Chemistry & …, 2023 - Wiley Online Library
In this work, the design, synthesis, and mechanistic studies of novel pyrazole‐based
benzofuran derivatives 1–8 as anticancer agents were discussed. Cytotoxic potency of the …
benzofuran derivatives 1–8 as anticancer agents were discussed. Cytotoxic potency of the …
[PDF][PDF] Synthesis, molecular modeling studies and biological evaluation of novel pyrazole derivatives as antitumor and EGFR inhibitors
S Walaa, NA Mohamed, S Weam, ES Nossier… - Int. J. Pharm …, 2016 - researchgate.net
In this study, a new series of 4-(5-methylisoxazol-3-ylamino) thiazole derivatives
incorporated with different heterocyclic moieties was synthesized and screened for their in …
incorporated with different heterocyclic moieties was synthesized and screened for their in …
[HTML][HTML] Design, synthesis, in silico toxicity prediction, molecular docking, and evaluation of novel pyrazole derivatives as potential antiproliferative agents
P Ravula, HB Vamaraju, M Paturi, NSC Jn, S Kolli - EXCLI journal, 2016 - ncbi.nlm.nih.gov
A new series of pyrazole derivatives were designed by docking into vascular endothelial
growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were …
growth factor receptor-2 (VEGFR-2) kinase active site. The designed compounds were …
Regioselective synthesis and biological studies of novel 1-aryl-3, 5-bis (het) aryl pyrazole derivatives as potential antiproliferative agents
Pyrazole moiety represents an important category of heterocyclic compound in
pharmaceutical and medicinal chemistry. The novel 1-aryl-3, 5-bis (het) aryl pyrazole …
pharmaceutical and medicinal chemistry. The novel 1-aryl-3, 5-bis (het) aryl pyrazole …
Design, synthesis, biological evaluation and molecular docking studies of novel benzofuran–pyrazole derivatives as anticancer agents
SS Abd El-Karim, MM Anwar, NA Mohamed, T Nasr… - Bioorganic …, 2015 - Elsevier
This study deals with design and synthesis of novel benzofuran–pyrazole hybrids as
anticancer agents. Eight compounds were chosen by National Cancer Institute (NCI), USA to …
anticancer agents. Eight compounds were chosen by National Cancer Institute (NCI), USA to …
In silico studies, synthesis and anticancer activity of novel diphenyl ether-based pyridine derivatives
A series of novel 2-amino-4-(3-hydroxy-4-phenoxyphenyl)-6-(4-substituted phenyl)
nicotinonitriles were synthesized and evaluated against HepG2, A-549 and Vero cell lines …
nicotinonitriles were synthesized and evaluated against HepG2, A-549 and Vero cell lines …
Synthesis, cytotoxicity of some pyrazoles and pyrazolo [1, 5-a] pyrimidines bearing benzothiazole moiety and investigation of their mechanism of action
EM Husseiny - Bioorganic Chemistry, 2020 - Elsevier
A novel series of pyrazoles and pyrazolo [1, 5-a] pyrimidines bearing benzothiazole moiety
were designed and synthesized. Chemical structures were confirmed by spectral data and …
were designed and synthesized. Chemical structures were confirmed by spectral data and …
Synthesis, characterization, molecular docking and in vitro anti-cancer activity studies of new and highly selective 1, 2, 3-triazole substituted 4-hydroxybenzohyrdazide …
In this study, 16 new hybrid compounds 6 (ah) and 7 (ah) were synthesized starting from
methylparaben. These new compounds consist of eight 1, 2, 3-triazole-arylidenehydrazide …
methylparaben. These new compounds consist of eight 1, 2, 3-triazole-arylidenehydrazide …
Synthesis of 1, 4-dihydropyrano [2, 3-c] pyrazole derivatives and exploring molecular and cytotoxic properties based on DFT and molecular docking studies
One-pot multicomponent reaction of ethyl 3-oxobutanoate or ethyl 3-oxo-3-
phenylpropanoate, hydrazine hydrate, malononitrile, various aldehydes in ethanolic …
phenylpropanoate, hydrazine hydrate, malononitrile, various aldehydes in ethanolic …