Bone metastasis, or the development of secondary tumors within the bone of cancer
patients, is a debilitating and incurable disease. Despite its morbidity, the biology of bone …

Metastasis to bones is determined by both intrinsic traits of metastatic tumor cells and
properties appertaining to the bone microenvironment. Bone marrow niches are critical for …

For metastasis to occur, tumor cells must first detach from their tissue of origin. This requires
altering both the tissue of origin and the cancer cell. Once detached, cancer cells in …

Breast cancer bone metastasis develops as the result of a series of complex interactions
between tumor cells, bone marrow cells, and resident bone cells. The net effect of these …

During the past decade preclinical studies have defined many of the mechanisms used by
tumours to hijack the skeleton and promote bone metastasis. This has led to the …

Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

The bone marrow has been long known to host a unique environment amenable to
colonization by metastasizing tumor cells. Yet, the underlying molecular interactions within …

Bone metastases are common complications of many cancers. Among the mechanisms that
set the scene for the development of bone metastases, several are shared by all forms of …

As one of the most common metastatic sites of malignancies, bone has a unique
microenvironment that allows metastatic tumor cells to grow and flourish. The fenestrated …

The bone is the third most common site of metastasis for a wide range of solid tumors
including lung, breast, prostate, colorectal, thyroid, gynecologic, and melanoma, with 70% of …