Current treatments for depression are inadequate for many individuals, and progress in
understanding the neurobiology of depression is slow. Several promising hypotheses of …

The molecular neurobiology of depression begins with the concept that depressive
disorders represent a family of related but distinct conditions. Different points of vulnerability …

The past 5 years have seen unprecedented advances in our knowledge about the
neurobiology of depression. Significant breakthroughs have been made in genomics …

BACKGROUND Research on the neurobiology of depression began in earnest in the late
1950s, when converging lines of evidence pointed to the possibility of dysfunction of CNS …

Previously, authors have reviewed the evidence pertaining to a wide range of
neurochemical, neuroendocrine, neurophysiological, and structural correlates of …

Major depressive disorder is a heritable psychiatric syndrome that appears to be associated
with subtle cellular and molecular alterations in a complex neural network. The affected …

Due to the clinical and etiological heterogeneity of major depressive disorder, it has been
difficult to elucidate its pathophysiology. Current neurobiological theories with the most valid …

Depression has become one of the most prevalent neuropsychiatric disorders characterized
by anhedonia, anxiety, pessimism, or even suicidal thoughts. Receptor theory has been …

After decades of effort, the field of depression research is far from understanding how
antidepressant drugs mediate their clinical effects. The time lag of 2–6 weeks of therapy that …

Depression is a common cause of mortality and morbidity, but the biological bases of the
deficits in emotional and cognitive processing remain incompletely understood. Current …