The folding of the chromatin filament and, in particular, the organization of genomic DNA
within metaphase chromosomes has attracted the interest of many laboratories during the …

The higher-order assembly of the approximately 30 nm chromatin fibers into the
characteristic morphology of HeLa mitotic chromosomes was investigated by electron …

In previous studies with partially denatured metaphase chromosomes, we detected platelike
structures instead of the chromatin fibers currently considered in different structural models …

In a previous work we observed multilayered plate-like structures surrounding partially
denatured HeLa chromosomes at metaphase ionic conditions. This unexpected finding has …

Metaphase chromosomes released from cells in the presence of Joklik's suspension media
by vortex-mixing with 0.5 mm glass beads have been analyzed by electron microscopy. In …

We have performed a very extensive electron microscopy investigation of the chromatin
structures extruded from partially denatured metaphase chromosomes from HeLa cells …

We have performed a very extensive investigation of chromatin folding in different buffers
over a wide range of ionic conditions similar to those found in eukaryotic cells. Our results …

How is a long strand of genomic DNA packaged into a mitotic chromosome or nucleus? The
nucleosome fiber (beads-on-a-string), in which DNA is wrapped around core histones, has …

The three-dimensional organization of tightly condensed chromatin within metaphase
chromosomes has been one of the most challenging problems in structural biology since the …

Using electron microscopy we show that the metaphase chromatin fibers of Chinese
hamster ovary cells form the same ionic strength-dependent higher order structures as the …