Acidic stress–ER stress axis for blunted activation of NF-κB in mesothelial cells exposed to peritoneal dialysis fluid

H Johno, R Ogata, S Nakajima… - Nephrology Dialysis …, 2012 - academic.oup.com
Background Bacterial peritonitis is a frequent complication in patients on peritoneal dialysis
(PD). We previously reported that PD fluid (PDF) suppressed expression of monocyte …

Impairment of MCP-1 expression in mesothelial cells exposed to peritoneal dialysis fluid by osmotic stress and acidic stress

R Ogata, N Hiramatsu, K Hayakawa… - Peritoneal dialysis …, 2011 - journals.sagepub.com
Background Bacterial peritonitis is one of the most frequent complications in patients on
peritoneal dialysis. In the present study, we investigated effects of peritoneal dialysis fluid …

Peritoneal dialysis fluid induces p38-dependent inflammation in human mesothelial cells

A Riesenhuber, K Kratochwill… - Peritoneal dialysis …, 2011 - journals.sagepub.com
Background Noninfectious upregulation of proinflammatory pathways in mesothelial cells
may represent an integral part of their stress response upon exposure to peritoneal dialysis …

[HTML][HTML] Prednisolone inhibits hyperosmolarity-induced expression of MCP-1 via NF-κB in peritoneal mesothelial cells

H Matsuo, M Tamura, N Kabashima, R Serino… - Kidney international, 2006 - Elsevier
The mechanism of peritoneal fibrosis in patients on continuous ambulatory peritoneal
dialysis (CAPD) is poorly elucidated. We investigated the cellular mechanism of high …

Establishment of a novel mouse peritoneal dialysis-associated peritoneal injury model

F Yu, J Chen, X Wang, Q Cai, J Luo, L Wang… - Clinical and …, 2022 - Springer
Background Peritoneal fibrosis induced by various factors during peritoneal dialysis (PD)
can eventually lead to ultrafiltration failure and termination of PD treatment. The existing …

Novel aspects of the immune response involved in the peritoneal damage in chronic kidney disease patients under dialysis

F Trionfetti, V Marchant, GT González-Mateo… - International Journal of …, 2023 - mdpi.com
Chronic kidney disease (CKD) incidence is growing worldwide, with a significant percentage
of CKD patients reaching end-stage renal disease (ESRD) and requiring kidney …

Biocompatibility reduces inflammation-induced apoptosis in mesothelial cells exposed to peritoneal dialysis fluid

B Santamaría, AC Ucero, A Benito-Martin, MJ Vicent… - Blood purification, 2015 - karger.com
Background/Aims: Peritonitis is a major complication that arises out of peritoneal dialysis
(PD), leading to death and loss of mesothelium and peritoneal injury, which may impede PD …

Alanyl–glutamine dipeptide restores the cytoprotective stress proteome of mesothelial cells exposed to peritoneal dialysis fluids

K Kratochwill, M Boehm, R Herzog… - Nephrology Dialysis …, 2012 - academic.oup.com
Background. Exposure of mesothelial cells to peritoneal dialysis fluids (PDF) results in
cytoprotective cellular stress responses (CSR) that counteract PDF-induced damage. In this …

Preventing peritoneal dialysis-associated fibrosis by therapeutic blunting of peritoneal toll-like receptor activity

AC Raby, MO Labéta - Frontiers in physiology, 2018 - frontiersin.org
Peritoneal dialysis (PD) is an essential daily life-saving treatment for end-stage renal failure.
PD therapy is limited by peritoneal inflammation, which leads to peritoneal membrane failure …

Impaired TGF-β signalling enhances peritoneal inflammation induced by E. Coli in rats

X Wang, J Nie, Z Jia, M Feng, Z Zheng… - Nephrology Dialysis …, 2010 - academic.oup.com
Background. Peritonitis is a common and severe complication of peritoneal dialysis (PD).
Although TGF-β is a key mediator in peritoneal fibrosis with chronic PD, its role in acute …