Role of mexA-mexB-oprM in antibiotic efflux in Pseudomonas aeruginosa

XZ Li, H Nikaido, K Poole - Antimicrobial agents and …, 1995 - Am Soc Microbiol
We have earlier described mexA-mexB-oprK, an operon involved in pyoverdine export in
Pseudomonas aeruginosa, and suggested that the products of these genes also contribute …

Expression of Pseudomonas aeruginosa Multidrug Efflux Pumps MexA-MexB-OprM and MexC-MexD-OprJ in a Multidrug-Sensitive Escherichia coli Strain

R Srikumar, T Kon, N Gotoh… - Antimicrobial agents and …, 1998 - Am Soc Microbiol
The mexCD-oprJ and mexAB-oprM operons encode components of two distinct multidrug
efflux pumps in Pseudomonas aeruginosa. To assess the contribution of individual …

Interplay between the MexA-MexB-OprM multidrug efflux system and the outer membrane barrier in the multiple antibiotic resistance of Pseudomonas aeruginosa

XZ Li, L Zhang, K Poole - Journal of Antimicrobial …, 2000 - academic.oup.com
MexAB-OprM is a constitutively expressed multidrug efflux system of Pseudomonas
aeruginosa. Using isogenic pump mutants, the contributions of the MexAB-OprM efflux pump …

In Vivo Emergence of Multidrug-Resistant Mutants ofPseudomonas aeruginosa Overexpressing the Active Efflux System MexA-MexB-OprM

I Ziha-Zarifi, C Llanes, T Köhler… - Antimicrobial Agents …, 1999 - Am Soc Microbiol
ABSTRACT During a 6-month period, 21 pairs of Pseudomonas aeruginosa isolates
susceptible (pretherapy) and resistant (posttherapy) to antipseudomonal β-lactam antibiotics …

Characterization of MexE–MexF–OprN, a positively regulated multidrug efflux system of Pseudomonas aeruginosa

T Ko¨ hler, M Michéa‐Hamzehpour… - Molecular …, 1997 - Wiley Online Library
Antibiotic‐resistant mutants of Pseudomonas aeruginosa were generated using
chloramphenicol and ciprofloxacin as selective agents. These mutants displayed a multidrug …

Assignment of the Substrate-Selective Subunits of the MexEF-OprN Multidrug Efflux Pump of Pseudomonas aeruginosa

H Maseda, H Yoneyama, T Nakae - Antimicrobial agents and …, 2000 - Am Soc Microbiol
Pseudomonas aeruginosa expresses a low level of the MexAB-OprM efflux pump and
shows natural resistance to many structurally and functionally diverse antibiotics. The …

Clinical Strains of Pseudomonas aeruginosa Overproducing MexAB-OprM and MexXY Efflux Pumps Simultaneously

C Llanes, D Hocquet, C Vogne… - Antimicrobial agents …, 2004 - Am Soc Microbiol
Simultaneous overexpression of the MexAB-OprM and MexXY efflux systems was
demonstrated by real-time reverse transcription-PCR and immunoblotting experiments for …

Inner membrane efflux components are responsible for beta-lactam specificity of multidrug efflux pumps in Pseudomonas aeruginosa

R Srikumar, XZ Li, K Poole - Journal of bacteriology, 1997 - Am Soc Microbiol
A major feature of the MexAB-OprM multidrug efflux pump which distinguishes it from the
MexCD-OprJ and MexEF-OprN multidrug efflux systems in Pseudomonas aeruginosa is its …

Contribution of the MexX-MexY-OprM Efflux System to Intrinsic Resistance in Pseudomonas aeruginosa

N Masuda, E Sakagawa, S Ohya, N Gotoh… - Antimicrobial agents …, 2000 - Am Soc Microbiol
To test the possibility that MexX-MexY, a new set of efflux system components, is associated
with OprM and contributes to intrinsic resistance in Pseudomonas aeruginosa, we …

Two Efflux Systems Expressed Simultaneously in Multidrug-Resistant Pseudomonas aeruginosa

L Pumbwe, LJV Piddock - Antimicrobial Agents and …, 2000 - Am Soc Microbiol
ABSTRACT Simultaneous overexpression of MexAB-OprM and MexEF-OprN was
demonstrated for a multiply antibiotic-resistant clinical isolate of Pseudomonas aeruginosa …