Advances in sample preparation and analytical techniques for lipidomics study of clinical samples

CC Teo, WPK Chong, E Tan, NB Basri, ZJ Low… - TrAC Trends in …, 2015 - Elsevier
Lipids play multiple key roles in biological systems, including acting as secondary energy
reserves, being components of cellular membranes and participating in cell-signaling …

[HTML][HTML] Recent advances towards mass spectrometry-based clinical lipidomics

S Salihovic, S Lamichane, T Hyötyläinen… - Current opinion in …, 2023 - Elsevier
The objective of this review is to provide a comprehensive summary of the latest
methodological advancements and emerging patterns in utilizing lipidomics in clinical …

Lipidomics: techniques, applications, and outcomes related to biomedical sciences

K Yang, X Han - Trends in biochemical sciences, 2016 - cell.com
Lipidomics is a newly emerged discipline that studies cellular lipids on a large scale based
on analytical chemistry principles and technological tools, particularly mass spectrometry …

Chewing the fat: How lipidomics is changing our understanding of human health and disease in 2022

C Géhin, SJ Fowler, DK Trivedi - Analytical Science Advances, 2023 - Wiley Online Library
Lipids are biological molecules that play vital roles in all living organisms. They perform
many cellular functions, such as 1) forming cellular and subcellular membranes, 2) storing …

Bioanalytical techniques in nontargeted clinical lipidomics

T Hyötyläinen, M Orešič - Bioanalysis, 2016 - Taylor & Francis
Lipidomic analysis aims at comprehensive characterization of molecular lipids in biological
systems. Due to the central role of lipid metabolism in many devastating diseases, lipidomics …

Optimizing the lipidomics workflow for clinical studies—practical considerations

T Hyötyläinen, M Orešič - Analytical and bioanalytical chemistry, 2015 - Springer
Lipidomics is increasingly being used in clinical research, offering new opportunities for
disease prediction and detection. One of the key challenges of clinical applications of …

[HTML][HTML] Recent advances in expanding the coverage of the lipidome

S Tumanov, JJ Kamphorst - Current opinion in biotechnology, 2017 - Elsevier
Highlights•The extreme diversity of the lipidome poses a significant analytical challenge.•A
variety of mass spectrometry-based approaches exist for the analysis of lipids.•Combining …

Lipidomic analysis

M Holčapek, G Liebisch, K Ekroos - 2018 - ACS Publications
The state-of-art in the lipidomic analysis is summarized here to provide the overview of
available sample preparation strategies, mass spectrometry (MS)-based methods for the …

Lipidomics from sample preparation to data analysis: a primer

T Züllig, M Trötzmüller, HC Köfeler - Analytical and bioanalytical chemistry, 2020 - Springer
Lipids are amongst the most important organic compounds in living organisms, where they
serve as building blocks for cellular membranes as well as energy storage and signaling …

Clinical lipidomics: realizing the potential of lipid profiling

TG Meikle, K Huynh, C Giles, PJ Meikle - Journal of lipid research, 2021 - ASBMB
Dysregulation of lipid metabolism plays a major role in the etiology and sequelae of
inflammatory disorders, cardiometabolic and neurological diseases, and several forms of …