The fibrin D-dimer degradation fragment is produced by plasmin degradation of cross-linked
fibrin. Elevated plasma D-dimer levels indicate increased plasmin degradation of cross …

Although abnormalities in coagulation tests have been reported during vaso-occlusive
crises in patients with sickle cell disease, objective, readily performed laboratory tests that …

Although the mechanisms involved in the persistent clinical complications of sickle cell
disease have not yet been fully delineated, previous studies suggest that sickle cell (HbSS) …

Objective: To evaluate the activation of clotting systems in patients with sickle cell disease
(SCD) by measuring the plasma D‐dimer level and to determine the effect of low‐dose …

Seventeen parameters of coagulation and fibrinolysis were measured in 33 patients with
sickle cell disease; 30 were tested in steady state (SS) and 19 in crisis (Cr). There were 16 …

Abnormalities of coagulation and fibrinolysis were studied in a group of 28 children and
young adults with homozygous sickle cell disease (SCD), either in the steady state (n= 12) …

Thirty-three subjects with sickle cell disease (SCD), 11 during episodes of pain and 22
during periods without pain, were evaluated for in vivo thrombogenic activities as compared …

Three patients with sickle-cell disease (SSD) were followed, weekly, for 112 to 2 years,
years, during which time they experienced one or more episodes of crisis. Crisis was …

Although large vessel thrombi are occasionally reported in patients with homozygous sickle
cell disease, the role of intravascular coagulation in typical pain crises is controversial …

A role for coagulation in the pathogenesis of sickle cell anemia (SCA) pain crisis has long
been suspected. We have observed evidence for in vivo coagulation in patients with SCA …