Abstract tRNA-guanine transglycosylase (TGT) is the enzyme responsible for the post-
transcriptional modification of specific tRNAs (Asn, Asp, His and Tyr) with queuine. In E. coli …

Revised Manuscript Received February 25, 1993 abstract: tRNA-guanine transglycosylase
(TGT) is the enzyme responsible for the post-transcriptional modification of specific tRNAs …

The enzyme tRNA− guanine transglycosylase (TGT, EC 2.4. 2.29) catalyzes a
posttranscriptional transglycosylation reaction involved in the incorporation of the modified …

Revised Manuscript Received August 14, 1995® abstract: A series of 5-substituted 2-
aminopyrrolo [2, 3-< i] pyrimidin-4 (3//)-ones have been synthesized in order to study the …

Previously, we have demonstrated that the tRNA-guanine transglycosylase (TGT) from
Escherichia coli is capable of utilizing an in vitro generated minihelix consisting of the …

In order to probe the interaction between tRNA and the tRNA hypermodifying enzyme, tRNA-
guanine transglycosylase (TGT) from Escherichia coli, we have undertaken the generation …

tRNA-guanine transglycosylase (TGT) catalyzes the exchange of queuine (or a precursor)
for guanine 34 in tRNA. The minimal RNA recognition motif for TGT has been found to …

tRNA–guanine transglycosylase (TGT) is a key enzyme in the post-transcriptional
modification of certain tRNAs with the pyrrolopyrimidine base queuine. TGT is required for …

The modified RNA base queuine [7-(4, 5-cis-dihydroxy-1-cyclopenten-3-ylaminomethyl)-7-
deazaguanine] is present in tRNA because of a unique base-exchange process catalyzed …

A key enzyme involved in the incorporation of the modified base queuine into tRNA (position
34) is tRNA-guanine transglycosylase (TGT). Studies of the recognition of truncated tRNAs …