Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

During aging, the mechanisms that normally maintain health and stress resistance strikingly
decline, resulting in decrepitude, frailty, and ultimately death. Exactly when and how this …

Aging is characterized by functional decline of diverse organs and an increased risk for
several diseases. Therefore, a high interest exists in understanding the molecular …

Aging is a complex process that results in compromised biological functions of the organism
and increased susceptibility to disease and death. Although the molecular basis of aging is …

A critical hallmark of aging is cellular senescence, a state of growth arrest and inflammatory
cytokine release in cells, caused by a variety of stresses. Recent work has convincingly …

Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to
changes in the underlying DNA sequence, most notably chromatin remodeling driven by …

Aging is associated with a wide range of human disorders, including cancer, diabetes,
cardiovascular, and neurodegenerative diseases. Long thought to be an inexorable road …

Organismal aging and longevity are influenced by many complex interacting factors.
Epigenetics has recently emerged as another possible determinant of aging. Here, we …

Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …