A randomized double-blind clinical trial was performed to test the safety and efficacy of a low-
molecular-weight heparin, tinzaparin (Innohep®), for the management of acute painful …

Background There are no approved treatments for vaso-occlusive crises in sickle cell
disease. Sevuparin is a novel non-anticoagulant low molecular weight heparinoid, with anti …

Sickle-cell disease (SCD) is a wide-spread inherited hemolytic anemia that is due to a point
mutation, leading to the substitution of valine for glutamic acid, causing a spectrum of clinical …

Intravenous morphine is the treatment of choice for severe pain during vaso‐occlusive crisis
in sickle cell disease (SCD). However, side effects of morphine may hamper effective …

The vaso-occlusive crisis, or sickle cell crisis, is a common painful complication of sickle cell
disease in adolescents and adults. Acute episodes of severe pain (crises) are the primary …

Abstract RheothRx (Glaxo Wellcome Inc, Research Triangle Park, NC; poloxamer 188)
Injection is a nonionic surfactant with hemorrheologic properties that suggest it may be …

A role for coagulation in the pathogenesis of sickle cell anemia (SCA) pain crisis has long
been suspected. We have observed evidence for in vivo coagulation in patients with SCA …

We have previously reported that long term daily administration of aspirin-dipyridamole
significantly improved laboratory findings indicative of disease activity in patients with sickle …

One of the major causes of hospitalization for patients with sickle cell disease (SCD) are
vaso-occlusive crises (VOC), which are characterized by acute pain and organ damage …

We have recently completed a double-blind, placebo-controlled, noncrossover study, the
goal of which was to determine whether cetiedil citrate (cetiedil) could affect the course of …