In human embryos, the initiation of transcription (embryonic genome activation [EGA]) occurs
by the eight-cell stage, but its exact timing and profile are unclear. To address this, we …

Studies of mammalian development have advanced our understanding of the genetic,
epigenetic, and cellular processes that orchestrate embryogenesis and have uncovered …

Differentiation of human embryonic stem cells (hESCs) provides a unique opportunity to
study the regulatory mechanisms that facilitate cellular transitions in a human context. To …

Mammalian embryonic stem (ES) cells can either self-renew or generate progenitor cells
that have a more restricted developmental potential. This provides an important model …

Cells of the early mammalian embryo, including pluripotent embryonic stem (ES) cells and
primordial germ cells (PGCs), are epigenetically dynamic and heterogeneous. During early …

Activation of transcription within the embryonic genome (EGA) after fertilization is a complex
process requiring a carefully coordinated series of nuclear and cytoplasmic events, which …

Establishing the different lineages of the early mammalian embryo takes place over several
days and several rounds of cell divisions from the fertilized egg. The resulting blastocyst …

Embryonic stem (ES) cells can replicate indefinitely while retaining the capacity to
differentiate into functionally distinct cell types. ES cells proliferate and differentiate without …

Here, we provide fundamental insights into early human development by single-cell RNA-
sequencing of human and mouse preimplantation embryos. We elucidate conserved …

Understanding lineage specification during human pre-implantation development is a
gateway to improving assisted reproductive technologies and stem cell research. Here we …