The electrophysiologic effects of ambasilide, a new class III antiarrhythmic drug reported to
be a nonselective blocker of both components (I Kr and I Ks) of the delayed-rectifier …

Specific blockers of the rapid component of the delayed outward rectifier current (l K r) such
as d-sotalol, dofetilide and E4031 prolong action potential duration in an inverse frequency …

Ambasilide (LU 47110) is a new class III antiarrhythmic drug with a unique profile of action in
mammals; however, the effects on human atrial repolarization are not known. We tested the …

Electrophysiologic effects of ambasilide in canine isolated cardiac muscle driven at 1 Hz and
in rabbit sinoatrial (SA) node preparations were determined by standard microelectrode …

We studied the effect of two new class III antiarrhythmics, ambasilide and dofetilide, on the
action potential duration (APD) of guinea pig right ventricular papillary muscle at different …

The aim of the study was to determine the in vitro rate-dependent cellular
electrophysiological effects of ambasilide (10 and 20 μM/l), a new investigational …

Objectives The effects of almokalant (4-[3-ethyl [3-(propylsulphinyl) propyl]-amino]-2-hydroxy-
propoxyj-benzonitrile), E-4031 (1-[2-(6-methyl-2-pyridyl)-ethyl]-4-(4-methylsulphonyl-amino …

Class III Antiarrhythmics and β‐Adrenergic Stimulation. Introduction: Blockade of the rapid
delayed rectifier potassium current (IKr) as an important mechanism for current Class III …

Certain class III antiarrhythmic agents manifest loss of effect at short cycle lengths (CLs).
This effect may limit their efficacy in the presence of tachycardia. We studied the frequency …

Rate Dependence of Azimilide and E‐4031. Introduction: Reverse rate‐dependence, a
lessening in Class III antiarrhythmic agent action potential duration (APD) prolongation as …