1. The evidence is accumulating to suggest that glycine, the simplest amino acid, is
conditionally essential in man. Benzoic acid, by conjugation with glycine to form hippuric …

Urinary 5-L-oxoproline was measured during normal pregnancies in Southampton, England
and Kingston, Jamaica. The CV of 5-L-oxoproline excretion in urine, determined over 7 d in …

The urinary excretion of 5‐oxoproline, which may be used as an index of glycine status, was
investigated in 30 normal pregnant women during different stages of pregnancy and in 18 …

We hypothesized that a limitation in the endogenous formation of glycine might constrain
catch-up growth during recovery from severe childhood malnutrition. The urinary excretion of …

A method for measuring 5-L-oxoproline in urine, which involves isolation by short-column
chromatography, acid hydrolysis to glutamic acid and enzymic assay of glutamic acid, was …

Urinary 5-L-oxoproline was measured in term and preterm infants from shortly after birth until
6 weeks of postnatal age to determine their ability to synthesise glycine. In term infants the …

The primary metabolic defect in 5-oxoprolinuria (pyroglutamic aciduria) is the lack of
glutathione synthetase. The mechanism of the concomitant overproduction of 5-oxoproline …

Enzyme studies on placenta, cultured skin fibroblasts, and erythrocytes from two sisters with
the inborn error 5-oxoprolinuria (pyroglutamic aciduria) indicate that the metabolic lesion in …

The effect of dietary control on the day-to-day variation in total hydroxyproline excretion has
been examined in two studies. In the first, a normal volunteer ate a controlled diet containing …

It was possible in this way to trace broadly the main features of amino-acid metabolism in the
mammal, as summarized, for instance, in fig. 1 (Dent, 1954). This shows that the main …